The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing (Q34569380)

3 August 2017

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title

The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing (English)

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3 August 2017

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1

W G Kaelin

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3 August 2017

publication date

1 January 2005

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Cold Spring Harbor Symposia on Quantitative Biology

3 August 2017

published in

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3 August 2017

volume

70

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3 August 2017

page(s)

159-166

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Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila

3 August 2017

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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von Hippel-Lindau tumor suppressor: not only HIF's executioner

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VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

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Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

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The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen

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Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

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Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

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Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

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Treatment of von Hippel-Lindau retinal hemangioblastoma by the vascular endothelial growth factor receptor inhibitor SU5416 is more effective for associated macular edema than for hemangioblastomas.

21 January 2018

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

21 January 2018

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Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

21 January 2018

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Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

21 January 2018

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

21 January 2018

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

21 January 2018

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

21 January 2018

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pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

21 January 2018

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Tumour suppression by the human von Hippel-Lindau gene product

21 January 2018

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

21 January 2018

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

21 January 2018

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Molecular basis of the VHL hereditary cancer syndrome

21 January 2018

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The von Hippel-Lindau tumor suppressor gene and kidney cancer

21 January 2018

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

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Role of VHL gene mutation in human cancer

21 January 2018

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

21 January 2018

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

21 January 2018

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The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

21 January 2018

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Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

21 January 2018

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Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

21 January 2018

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SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons

21 January 2018

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Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Antiangiogenic therapy for von Hippel-Lindau disease

21 January 2018

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The pressure rises: update on the genetics of phaeochromocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Germ-line mutations in nonsyndromic pheochromocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Isolation and characterization of the full-length 3' untranslated region of the human von Hippel-Lindau tumor suppressor gene

21 January 2018

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https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.001

The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways

21 January 2018

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

VHL gene deletion and enhanced VEGF gene expression detected in the stromal cells of retinal angioma

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Identification of the von Hippel-Lindau disease tumor suppressor gene

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/SQB.2005.70.001

Identifiers

DOI

10.1101/SQB.2005.70.001

1 reference

3 August 2017

1 reference