PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells (Q34570823)

3 August 2017

PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells (English)

1 reference

3 August 2017

0 references

1 reference

Seung-Hoi Koo

3

0 references

author name string

Hyo-Sup Kim

1

1 reference

3 August 2017

You-Cheol Hwang

2

1 reference

3 August 2017

Kyong Soo Park

4

1 reference

3 August 2017

Myung-Shik Lee

5

1 reference

3 August 2017

Kwang-Won Kim

6

1 reference

3 August 2017

Moon-Kyu Lee

7

1 reference

3 August 2017

language of work or name

English

0 references

publication date

23 January 2013

1 reference

3 August 2017

1 reference

3 August 2017

8

1 reference

3 August 2017

1

1 reference

3 August 2017

e50128

1 reference

Creative Commons Attribution 4.0 International

3 August 2017

start time

23 January 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice

7 July 2018

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Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in rats.

7 July 2018

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Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor.

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Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure

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Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease

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Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion

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Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells

7 July 2018

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Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells

7 July 2018

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Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway

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GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

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Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells

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Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.

7 July 2018

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Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion

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Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release

7 July 2018

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Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells

7 July 2018

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Effect of PPAR-gamma activation and inhibition on glucose-stimulated insulin release in INS-1e cells

7 July 2018

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https://pubmed.ncbi.nlm.nih.gov/23372643

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based on heuristic

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Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553172

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs

7 July 2018

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The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

7 July 2018

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

7 July 2018

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Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

7 July 2018

1 reference

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Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells

7 July 2018

1 reference

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7 July 2018

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Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

7 July 2018

1 reference

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Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats

7 July 2018

1 reference

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Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553172

PPAR-gamma overexpression suppresses glucose-induced proinsulin biosynthesis and insulin release synergistically with pioglitazone in MIN6 cells

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Rosiglitazone (BRL 49653) enhances insulin secretory response via phosphatidylinositol 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Reduction in voltage-gated K+ currents in primary cultured rat pancreatic beta-cells by linoleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Insulin-sparing effects of troglitazone in rat pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050128

The free fatty acid receptor GPR40 generates excitement in pancreatic beta-cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23372643

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0050128

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference