Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets (Q34796756)

4 August 2017

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets (English)

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4 August 2017

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Kathrin Maedler

1

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author name string

Pavel Sergeev

2

1 reference

4 August 2017

Frédéric Ris

3

1 reference

4 August 2017

José Oberholzer

4

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4 August 2017

Helen I Joller-Jemelka

5

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4 August 2017

Giatgen A Spinas

6

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4 August 2017

Nurit Kaiser

7

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4 August 2017

Philippe A Halban

8

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4 August 2017

Marc Y Donath

9

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4 August 2017

language of work or name

English

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publication date

1 September 2002

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Journal of Clinical Investigation

4 August 2017

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4 August 2017

110

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4 August 2017

851-860

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4 August 2017

6

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beta-Cell death during progression to diabetes

4 August 2017

1 reference

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The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes

8 July 2018

1 reference

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High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

8 July 2018

1 reference

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Human islet transplantation: lessons from 13 autologous and 13 allogeneic transplantations

8 July 2018

1 reference

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Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?

8 July 2018

1 reference

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How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

8 July 2018

1 reference

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Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

8 July 2018

1 reference

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Processing of engulfed apoptotic bodies yields T cell epitopes

8 July 2018

1 reference

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Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus

8 July 2018

1 reference

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Long-term effects of aminoguanidine on insulin release and biosynthesis: evidence that the formation of advanced glycosylation end products inhibits B cell function

8 July 2018

1 reference

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Mouse islet cell lysis mediated by interleukin-1-induced Fas.

8 July 2018

1 reference

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The role of interleukin-1 in the pathogenesis of IDDM.

8 July 2018

1 reference

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Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

8 July 2018

1 reference

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Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene

8 July 2018

1 reference

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Hyperproinsulinemia and insulin deficiency in the diabetic Psammomys obesus.

8 July 2018

1 reference

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The intraislet macrophage and type I diabetes.

8 July 2018

1 reference

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Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism

8 July 2018

1 reference

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Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Automated method for isolation of human pancreatic islets

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Type II diabetes, glucose "non-sense," and islet desensitization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Activation of intraislet lymphoid cells causes destruction of islet cells

8 July 2018

1 reference

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Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

8 July 2018

1 reference

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Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations

8 July 2018

1 reference

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Antibodies to Glutamic Acid Decarboxylase Discriminate Major Types of Diabetes Mellitus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

8 July 2018

1 reference

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Apoptosis-inducing membrane vesicles. A novel agent with unique properties

8 July 2018

1 reference

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Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes

26 October 2018

1 reference

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Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I.

26 October 2018

1 reference

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Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

26 October 2018

1 reference

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Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes

26 October 2018

1 reference

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Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151125

Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

26 October 2018

1 reference

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Improved human islet isolation using a new enzyme blend, liberase

26 October 2018

1 reference

12 December 2020

Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes

1 reference

12 December 2020

Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage

1 reference

12 December 2020

Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor

1 reference

12 December 2020

Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis

1 reference

12 December 2020

Cytokines cause functional and structural damage to isolated islets of Langerhans

1 reference

12 December 2020

Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

1 reference

12 December 2020

Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans

1 reference

12 December 2020

Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans

1 reference

12 December 2020

1 reference

12 December 2020

Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture

1 reference

12 December 2020

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion

1 reference

12 December 2020

Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes

1 reference

12 December 2020

Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes

1 reference

12 December 2020

Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation

1 reference

12 December 2020

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI200215318

1 reference

4 August 2017

1 reference

4 August 2017

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