Emerging links between hypermutation of antibody genes and DNA polymerases (Q34572184)

3 August 2017

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title

Emerging links between hypermutation of antibody genes and DNA polymerases (English)

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3 August 2017

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Gearhart PJ

1

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3 August 2017

Wood RD

series ordinal

2

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3 August 2017

language of work or name

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1 December 2001

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

1

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3 August 2017

issue

3

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3 August 2017

page(s)

187-192

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Variability in the Lambda Light Chain Sequences of Mouse Antibody

3 August 2017

cites work

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Sequences of mouse immunoglobulin light chain genes before and after somatic changes

21 January 2018

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A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody

21 January 2018

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Somatic mutation of immunoglobulin light-chain variable-region genes

21 January 2018

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Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

21 January 2018

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Antibody diversity: somatic hypermutation of rearranged VH genes

21 January 2018

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Clusters of point mutations are found exclusively around rearranged antibody variable genes

21 January 2018

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Intraclonal generation of antibody mutants in germinal centres

21 January 2018

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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells

21 January 2018

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Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes

21 January 2018

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Analysis of somatic mutation in five B cell subsets of human tonsil

21 January 2018

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

21 January 2018

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Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice

21 January 2018

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Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

21 January 2018

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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

21 January 2018

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

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Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

21 January 2018

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Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

21 January 2018

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DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

21 January 2018

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Both DNA strands of antibody genes are hypermutation targets

21 January 2018

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Base substitution mutagenesis by terminal transferase: its role in somatic mutagenesis

21 January 2018

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Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

21 January 2018

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The reverse transcriptase model of somatic hypermutation

21 January 2018

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Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

21 January 2018

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Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene

21 January 2018

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A new DNA polymerase species from Drosophila melanogaster: a probable mus308 gene product.

21 January 2018

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DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis

21 January 2018

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Evidence that replication fork components catalyze establishment of cohesion between sister chromatids

21 January 2018

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Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p

21 January 2018

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Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

21 January 2018

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The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

21 January 2018

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DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

21 January 2018

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Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation

21 January 2018

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Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro.

21 January 2018

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Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.

21 January 2018

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Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.

21 January 2018

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Sez4 gene encoding an elongation subunit of DNA polymerase zeta is required for normal embryogenesis.

21 January 2018

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The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light

21 January 2018

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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

21 January 2018

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Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

21 January 2018

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Error-prone lesion bypass by human DNA polymerase eta.

21 January 2018

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Low fidelity DNA synthesis by human DNA polymerase-eta

21 January 2018

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Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis

21 January 2018

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Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication

21 January 2018

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Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells

21 January 2018

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Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta

21 January 2018

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Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

21 January 2018

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Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.

21 January 2018

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DNA polymerase mu, a candidate hypermutase?

21 January 2018

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DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells

21 January 2018

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Two novel human and mouse DNA polymerases of the polX family

21 January 2018

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Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota

21 January 2018

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Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

21 January 2018

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Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

21 January 2018

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A hyperconversion mechanism generates the chicken light chain preimmune repertoire

21 January 2018

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Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase

21 January 2018

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The human REV1 gene codes for a DNA template-dependent dCMP transferase

21 January 2018

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TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

21 January 2018

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The expanding polymerase universe

21 January 2018

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Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

21 January 2018

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Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

21 January 2018

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Origin of Antibody Variation

21 January 2018

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Mechanism of antigen-driven selection in germinal centres

21 January 2018

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Mechanism of antibody diversity: germ line basis for variability

21 January 2018

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7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

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7 January 2021

Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs

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7 January 2021

DNA repair: knockouts still mutating after first round

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7 January 2021

Ig gene hypermutation: a mechanism is due.

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7 January 2021

Differential expression of DNA polymerase epsilon in resting and activated B lymphocytes is consistent with an in vivo role in replication and not repair

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7 January 2021

Identifiers

DOI

10.1038/35105009

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Dimensions Publication ID

3 August 2017

1016576374

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