Strategies for designing and optimizing new generation vaccines (Q34572198)

3 August 2017

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title

Strategies for designing and optimizing new generation vaccines (English)

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3 August 2017

1

Berzofsky JA

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3 August 2017

Ahlers JD

2

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PubMed ID

11905830

3 August 2017

Belyakov IM

series ordinal

3

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3 August 2017

1 December 2001

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Nature Reviews Immunology

3 August 2017

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3 August 2017

1

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3 August 2017

209-219

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3 August 2017

3

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Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections

3 August 2017

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Epitope selection and design of synthetic vaccines. Molecular approaches to enhancing immunogenicity and cross-reactivity of engineered vaccines

21 January 2018

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T Cell Tolerance Based on Avidity Thresholds Rather Than Complete Deletion Allows Maintenance of Maximal Repertoire Diversity

21 January 2018

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Amino-terminal alteration of the HLA-A*0201-restricted human immunodeficiency virus pol peptide increases complex stability and in vitro immunogenicity

21 January 2018

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Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions

21 January 2018

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Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

21 January 2018

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Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence

21 January 2018

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High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection

21 January 2018

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MHC ligands and peptide motifs: first listing

21 January 2018

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Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

21 January 2018

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Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides.

21 January 2018

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Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries

21 January 2018

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Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy

21 January 2018

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Structural features of peptide analogs of human histocompatibility leukocyte antigen class I epitopes that are more potent and immunogenic than wild-type peptide

21 January 2018

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Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant

21 January 2018

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Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

21 January 2018

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Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides

21 January 2018

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Two intermediate-avidity cytotoxic T lymphocyte clones with a disparity between functional avidity and MHC tetramer staining

21 January 2018

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Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8alphabeta versus CD8alphaalpha expression

21 January 2018

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Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL

21 January 2018

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Supraoptimal peptide-major histocompatibility complex causes a decrease in bc1-2 levels and allows tumor necrosis factor alpha receptor II-mediated apoptosis of cytotoxic T lymphocytes

21 January 2018

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Induction of apoptosis in mature T cells by tumour necrosis factor

21 January 2018

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High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL.

21 January 2018

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Immunization with antigen and interleukin 2 in vivo overcomes Ir gene low responsiveness

21 January 2018

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Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific CTL.

21 January 2018

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Genetic adjuvants for DNA vaccines

21 January 2018

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Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity

21 January 2018

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Prevention of vaccinia virus infection in immunodeficient mice by vector-directed IL-2 expression

21 January 2018

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Recovery of immunodeficient mice from a vaccinia virus/IL-2 recombinant infection

21 January 2018

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Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

21 January 2018

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Control of homeostasis of CD8+ memory T cells by opposing cytokines.

21 January 2018

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Regulating the immune response to transplants. a role for CD4+ regulatory cells?

21 January 2018

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IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine

21 January 2018

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Modulation of cellular responses by plasmid CD40L: CD40L plasmid vectors enhance antigen-specific helper T cell type 1 CD4+ T cell-mediated protective immunity against herpes simplex virus type 2 in vivo

21 January 2018

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Improvement of chronic diarrhoea in patients with advanced HIV-1 infection during potent antiretroviral therapy

21 January 2018

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Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection

21 January 2018

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Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

21 January 2018

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Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

21 January 2018

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Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.

21 January 2018

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HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi.

21 January 2018

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Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge

21 January 2018

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The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12.

21 January 2018

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Induction of mucosal homing virus-specific CD8(+) T lymphocytes by attenuated simian immunodeficiency virus

21 January 2018

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Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity

21 January 2018

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Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection

21 January 2018

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Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques

21 January 2018

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A rational basis for mucosal vaccination against HIV infection

21 January 2018

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Mucosal immune system of the human genital tract

21 January 2018

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The effect of route of immunization on mucosal immunity and protection

21 January 2018

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Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants

21 January 2018

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Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.

21 January 2018

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Mucosal immunity and tolerance: relevance to vaccine development

21 January 2018

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Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression

21 January 2018

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The role of gammadelta T cells in generating antiviral factors and beta-chemokines in protection against mucosal simian immunodeficiency virus infection

21 January 2018

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Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract

21 January 2018

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Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites

21 January 2018

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Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses

21 January 2018

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

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Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

21 January 2018

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

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Molecular basis of T cell inactivation by CTLA-4

21 January 2018

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Enhancement of antitumor immunity by CTLA-4 blockade

21 January 2018

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Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses

21 January 2018

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21 January 2018

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DNA vaccines: immunology, application, and optimization*

21 January 2018

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Venezuelan equine encephalitis virus vectors expressing HIV-1 proteins: vector design strategies for improved vaccine efficacy

21 January 2018

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Human immunodeficiency virus type 1-specific immunity after genetic immunization is enhanced by modification of Gag and Pol expression

21 January 2018

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Increased DNA vaccine delivery and immunogenicity by electroporation in vivo

21 January 2018

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Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization.

21 January 2018

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Genetic immunization is a simple method for eliciting an immune response

21 January 2018

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Oral somatic transgene vaccination using attenuated S. typhimurium.

21 January 2018

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Unique immunogenicity of hepatitis B virus DNA vaccine presented by live-attenuated Salmonella typhimurium.

21 January 2018

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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

21 January 2018

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Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.

21 January 2018

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DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice.

21 January 2018

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Defined flanking spacers and enhanced proteolysis is essential for eradication of established tumors by an epitope string DNA vaccine

21 January 2018

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Vaccinia virus: a tool for research and vaccine development

21 January 2018

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Development of a preventive vaccine for Ebola virus infection in primates

21 January 2018

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Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime

21 January 2018

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Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

21 January 2018

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Modulation of cellular and humoral immune responses to a multiepitopic HIV-1 DNA vaccine by interleukin-18 DNA immunization/viral protein boost

21 January 2018

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Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines

21 January 2018

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Dendritic cells and the control of immunity

21 January 2018

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Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation

21 January 2018

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Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens

21 January 2018

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CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo

21 January 2018

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Induction of CD8+ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells

21 January 2018

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Dendritic cells in antitumor immune responses. II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice, are effective antigen carriers in the therapy of established tumors.

21 January 2018

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Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines

21 January 2018

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Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo

21 January 2018

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Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells.

21 January 2018

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Mature dendritic cells boost functionally superior CD8(+) T-cell in humans without foreign helper epitopes

21 January 2018

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Differentiation of T regulatory cells by immature dendritic cells

21 January 2018

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A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell.

21 January 2018

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Help for cytotoxic-T-cell responses is mediated by CD40 signalling.

21 January 2018

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T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.

21 January 2018

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Modulating the immune response with dendritic cells and their growth factors

21 January 2018

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Immunobiology of dendritic cells

21 January 2018

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Dendritic cell regulation of TH1-TH2 development

21 January 2018

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Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

21 January 2018

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Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells.

21 January 2018

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Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals

21 January 2018

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RNA-transfected dendritic cells in cancer immunotherapy

21 January 2018

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Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

21 January 2018

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Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application

21 January 2018

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Dendritic cells in cancer immunotherapy

21 January 2018

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Development of a clinical-scale method for generation of dendritic cells from PBMC for use in cancer immunotherapy

21 January 2018

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Dendritic cells: at the clinical crossroads

21 January 2018

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Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma

21 January 2018

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Novel immunologic approaches to the management of malignant melanoma

21 January 2018

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Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells

21 January 2018

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Idiotype vaccination using dendritic cells after autologous peripheral blood progenitor cell transplantation for multiple myeloma

21 January 2018

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Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo

21 January 2018

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Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells

21 January 2018

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CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

21 January 2018

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Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complex

21 January 2018

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7 January 2021

Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR

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7 January 2021

TCR avidity: it's not how strong you make it, it's how you make it strong

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7 January 2021

Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

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7 January 2021

Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens

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7 January 2021

Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination

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7 January 2021

Mechanisms of cytokine synergy essential for vaccine protection against viral challenge

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7 January 2021

Signals delivered through TCR instruct IL-12 receptor (IL-12R) expression: IL-12 and tumor necrosis factor-alpha synergize for IL-12R expression at low antigen dose

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7 January 2021

Vaccination with a recombinant vaccinia vaccine containing the B7-1 co-stimulatory molecule causes no significant toxicity and enhances T cell-mediated cytotoxicity

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7 January 2021

Development of a multicomponent candidate vaccine for HIV-1

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7 January 2021

Induction of a mucosal cytotoxic T-lymphocyte response by intrarectal immunization with a replication-deficient recombinant vaccinia virus expressing human immunodeficiency virus 89.6 envelope protein.

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7 January 2021

Prime-boost immunization with DNA vaccine: mucosal route of administration changes the rules

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7 January 2021

Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques

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7 January 2021

Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity

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7 January 2021

The role of cAMP in mucosal adjuvanticity of Escherichia coli heat-labile enterotoxin (LT)

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7 January 2021

NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway

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7 January 2021

Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma

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7 January 2021

Cutting edge: spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice

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7 January 2021

CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism

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7 January 2021

Delivery systems for gene-based vaccines

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7 January 2021

Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes.

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7 January 2021

Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity

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7 January 2021

The immune response to a DNA vaccine can be modulated by co-delivery of cytokine genes using a DNA prime-protein boost strategy

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7 January 2021

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

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7 January 2021

HIV-induced immunopathogenesis

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7 January 2021

Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy

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7 January 2021

The dendritic cell and human cancer vaccines

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7 January 2021

Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells

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7 January 2021

HIV-1 DNA vaccines and chemokines.

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7 January 2021

Identifiers

DOI

10.1038/35105075

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3 August 2017

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PubMed ID

11905830