Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). (Q34574445)

3 August 2017

title

Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). (English)

1 reference

3 August 2017

3

John M Sedivy

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3 August 2017

Isil Guney

1

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3 August 2017

Shirley Wu

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

28 February 2006

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Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

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3 August 2017

volume

103

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3 August 2017

issue

10

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3 August 2017

page(s)

3645-3650

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Ink4a/Arf expression is a biomarker of aging

3 August 2017

cites work

1 reference

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Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling

7 July 2018

1 reference

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

7 July 2018

1 reference

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A DNA damage checkpoint response in telomere-initiated senescence

7 July 2018

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Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

7 July 2018

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DNA damage foci at dysfunctional telomeres

7 July 2018

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

7 July 2018

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Werner syndrome protein limits MYC-induced cellular senescence

7 July 2018

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

7 July 2018

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7 July 2018

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Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

7 July 2018

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7 July 2018

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A large scale genetic analysis of c-Myc-regulated gene expression patterns

7 July 2018

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Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

7 July 2018

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7 July 2018

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

21 January 2018

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Ink4a/Arf expression is a biomarker of aging

21 January 2018

1 reference

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The tumor-suppressive functions of the human INK4A locus

21 January 2018

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Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16537449

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/16537449

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0600069103

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference