Reelin, lipoprotein receptors and synaptic plasticity (Q34575575)

3 August 2017

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title

Reelin, lipoprotein receptors and synaptic plasticity (English)

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3 August 2017

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Joachim Herz

1

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3 August 2017

Ying Chen

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 November 2006

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Nature Reviews Neuroscience

3 August 2017

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3 August 2017

7

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3 August 2017

11

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3 August 2017

850-859

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https://scigraph.springernature.com/pub.10.1038/nrn2009

3 August 2017

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cites work

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

31 March 2020

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Reelin is a ligand for lipoprotein receptors

31 March 2020

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Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation

31 March 2020

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Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

31 March 2020

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

31 March 2020

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CNS synaptogenesis promoted by glia-derived cholesterol

31 March 2020

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31 March 2020

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Two new mutants, ‘trembler’ and ‘reeler’, with neurological actions in the house mouse (Mus musculus L.)

31 March 2020

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Dysfunction of the Orleans reeler gene arising from exon skipping due to transposition of a full-length copy of an active L1 sequence into the skipped exon

31 March 2020

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Role of the reelin signaling pathway in central nervous system development

31 March 2020

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Reelin and brain development

31 March 2020

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Laminating the hippocampus

31 March 2020

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Neocortical histogenesis in normal and reeler mice: a developmental study based upon [3H]thymidine autoradiography.

31 March 2020

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Time of origin or corresponding cell classes in the cerebral cortex of normal and reeler mutant mice: an autoradiographic analysis.

31 March 2020

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Anatomical, Physiological and biochemical studies of the cerebellum fromreelermutant mouse

31 March 2020

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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

31 March 2020

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Neuronal position in the developing brain is regulated by mouse disabled-1

31 March 2020

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Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice

31 March 2020

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Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration

31 March 2020

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Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

31 March 2020

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The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons

31 March 2020

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Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning

31 March 2020

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Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes

31 March 2020

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Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

31 March 2020

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Crystal structures of the Dab homology domains of mouse disabled 1 and 2

31 March 2020

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Receptor clustering is involved in Reelin signaling

31 March 2020

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Reconstitution of the Reelin signaling pathway in fibroblasts demonstrates that Dab1 phosphorylation is independent of receptor localization in lipid rafts

31 March 2020

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Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody

31 March 2020

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Reelin activates SRC family tyrosine kinases in neurons

31 March 2020

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Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development

31 March 2020

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Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta

31 March 2020

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Interaction of reelin signaling and Lis1 in brain development

31 March 2020

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Regulation of protein tyrosine kinase signaling by substrate degradation during brain development

31 March 2020

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Disabled1 regulates the intracellular trafficking of reelin receptors

31 March 2020

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Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1.

31 March 2020

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Lipoprotein receptors in the nervous system

31 March 2020

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Apolipoprotein E receptors: linking brain development and Alzheimer's disease

31 March 2020

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Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade

31 March 2020

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Genetic modulation of tau phosphorylation in the mouse.

31 March 2020

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The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

31 March 2020

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DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing

31 March 2020

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The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors

31 March 2020

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ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes

31 March 2020

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alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons

31 March 2020

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Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.

31 March 2020

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Lipid rafts and signal transduction

31 March 2020

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Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

31 March 2020

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APP processing and synaptic function

31 March 2020

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A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve

31 March 2020

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Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

31 March 2020

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Synaptic efficacy enhanced by glial cells in vitro.

31 March 2020

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Neurodegeneration in the central nervous system of apoE-deficient mice

31 March 2020

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Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

31 March 2020

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Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

31 March 2020

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Brain cholesterol turnover required for geranylgeraniol production and learning in mice

31 March 2020

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Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

31 March 2020

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Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.

31 March 2020

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AMPA receptor regulation and LTP in the hippocampus of young and aged apolipoprotein E-deficient mice

31 March 2020

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LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD.

31 March 2020

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Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse.

31 March 2020

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ApoE isoform affects LTP in human targeted replacement mice.

31 March 2020

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Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E.

31 March 2020

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Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

31 March 2020

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Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

31 March 2020

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

31 March 2020

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

31 March 2020

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The aging brain: the cognitive reserve hypothesis and hominid evolution

31 March 2020

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Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

31 March 2020

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Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues.

31 March 2020

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Tissue plasminogen activator in central nervous system physiology and pathology.

31 March 2020

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Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior

31 March 2020

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An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus

31 March 2020

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Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition

31 March 2020

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Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF.

31 March 2020

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Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway.

31 March 2020

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The medial ganglionic eminence gives rise to a population of early neurons in the developing cerebral cortex.

31 March 2020

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Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

31 March 2020

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Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity

31 March 2020

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Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

31 March 2020

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The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

31 March 2020

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Reelin modulates NMDA receptor activity in cortical neurons.

31 March 2020

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Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor

31 March 2020

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Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin

31 March 2020

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Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice

31 March 2020

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Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro.

31 March 2020

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Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway

31 March 2020

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Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections.

31 March 2020

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A role for Cajal-Retzius cells and reelin in the development of hippocampal connections.

31 March 2020

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Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study

31 March 2020

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A decrease of reelin expression as a putative vulnerability factor in schizophrenia

31 March 2020

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Altered levels of Reelin and its isoforms in schizophrenia and mood disorders

31 March 2020

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Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression

31 March 2020

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Reelin signaling is impaired in autism

31 March 2020

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A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development

31 March 2020

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Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolation

31 March 2020

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Reelin promoter hypermethylation in schizophrenia

31 March 2020

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Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus

31 March 2020

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Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy

31 March 2020

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Components of the reelin signaling pathway are expressed in the spinal cord

31 March 2020

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Reelin controls position of autonomic neurons in the spinal cord

31 March 2020

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Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord

31 March 2020

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Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations

31 March 2020

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Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification

31 March 2020

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Mouse model of subretinal neovascularization with choroidal anastomosis

31 March 2020

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Signaling by Eph receptors and their ephrin ligands.

31 March 2020

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The Eph family: a multitude of receptors that mediate cell recognition signals

31 March 2020

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Hippocampal plasticity requires postsynaptic ephrinBs.

31 March 2020

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Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity

31 March 2020

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The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function

31 March 2020

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EphB receptors interact with NMDA receptors and regulate excitatory synapse formation

31 March 2020

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Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors

31 March 2020

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Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

31 March 2020

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

31 March 2020

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Regulation of NMDA receptor trafficking by amyloid-beta

31 March 2020

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Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination

31 March 2020

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Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons

31 March 2020

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Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning

31 March 2020

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NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein

31 March 2020

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Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1

31 March 2020

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Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration

31 March 2020

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A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system

31 March 2020

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Extracellular matrix molecules and synaptic plasticity: immunomapping of intracellular and secreted Reelin in the adult rat brain

31 March 2020

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Protein kinase C modulates NMDA receptor trafficking and gating

31 March 2020

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Dopamine D1 receptor-dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane.

31 March 2020

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Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation.

31 March 2020

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Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalization.

31 March 2020

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN2009

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Dimensions Publication ID

3 August 2017

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