Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. (Q41671941)

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8 December 2019

title

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration (English)

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L Mucke

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8 December 2019

author name string

M Buttini

1

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S Bellosta

3

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H Akeefe

4

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R E Pitas

5

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T Wyss-Coray

6

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R W Mahley

8

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language of work or name

English

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publication date

1 June 1999

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8 December 2019

published in

Journal of Neuroscience

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8 December 2019

volume

19

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page(s)

4867-4880

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issue

12

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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

8 December 2019

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Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

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Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele

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Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

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Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

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Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells

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Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: implications for Alzheimer's disease.

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Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation

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Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation.

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Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice

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Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the rat

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Expression of apolipoprotein E during nerve degeneration and regeneration

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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

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Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury

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Hippocampal damage produced by systemic injections of domoic acid in mice.

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Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia.

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Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

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Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

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Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

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Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4.

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Association of apolipoprotein E polymorphism with outcome after head injury.

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Correlations of synaptic and pathological markers with cognition of the elderly

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Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease.

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Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms

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12 December 2020

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets

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Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

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Spectrum of human immunodeficiency virus-associated neocortical damage

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Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man

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Isolation and characterization of apolipoprotein E

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12 December 2020

An improved T1/A ribonuclease protection assay.

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12 December 2020

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

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12 December 2020

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

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12 December 2020

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

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A Method for Obtaining Cerebrospinal Fluid from Mice

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Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.

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12 December 2020

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

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Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

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Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse.

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12 December 2020

Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease.

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12 December 2020

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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12 December 2020

Specific regional transcription of apolipoprotein E in human brain neurons

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12 December 2020

Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.

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12 December 2020

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Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease.

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

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12 December 2020

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12 December 2020

Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.

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12 December 2020

Complete cerebral ischemia with short-term survival in rat induced by cardiac arrest. II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain

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12 December 2020

Amyloid beta-protein, APOE genotype and head injury

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12 December 2020

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

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12 December 2020

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

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Novel role of human CD4 molecule identified in neurodegeneration

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High and low annealing temperatures increase both specificity and yield in touchdown and stepdown PCR.

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Human apolipoprotein E. The complete amino acid sequence

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12 December 2020

10.1523/JNEUROSCI.19-12-04867.1999

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DOI

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