Wnt signaling: a key regulator of bone mass (Q34583328)

3 August 2017

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title

Wnt signaling: a key regulator of bone mass (English)

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3 August 2017

3

Sergio Roman-Roman

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author name string

Roland Baron

series ordinal

1

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PubMed ID

17118265

3 August 2017

Georges Rawadi

series ordinal

2

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PubMed ID

17118265

3 August 2017

Sergio Roman-Roman

series ordinal

3

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3 August 2017

1 January 2006

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Current Topics in Developmental Biology

3 August 2017

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3 August 2017

76

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3 August 2017

103-127

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Ci: a complex transducer of the hedgehog signal

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

High bone mass in mice expressing a mutant LRP5 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Wnt signaling: an embarrassment of receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Regulation of osteoblastogenesis and bone mass by Wnt10b

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

High bone density due to a mutation in LDL-receptor-related protein 5

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Osteoclast differentiation and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Bone morphogenetic proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

GSK-3: tricks of the trade for a multi-tasking kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Association of functionally different RUNX2 P2 promoter alleles with BMD.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

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https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

The natural history of sclerosteosis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Cloning of a novel member of the low-density lipoprotein receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein

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https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Essential role of beta-catenin in postnatal bone acquisition

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https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A new secreted protein that binds to Wnt proteins and inhibits their activities

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

New aspects of Wnt signaling pathways in higher vertebrates

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Characterization of human bone morphogenetic protein (BMP)-4 and -7 gene promoters: activation of BMP promoters by Gli, a sonic hedgehog mediator

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A molecular mechanism for the effect of lithium on development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Functional and structural diversity of the human Dickkopf gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Developmental biology: signalling polarity.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

The promise and perils of Wnt signaling through beta-catenin.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Wnt signals are targets and mediators of Gli function.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

An LDL-receptor-related protein mediates Wnt signalling in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Tcf/Lef transcription factors during T-cell development: unique and overlapping functions

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Frizzled signalling and cell polarisation in Drosophila and vertebrates

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A mechanism for Wnt coreceptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

Alleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fracture

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

BMP signaling in skeletal development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2976004-5

7 January 2021

10.1016/S0070-2153(06)76004-5

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

17118265