Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice (Q34583970)

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English	Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice	scientific article

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3 August 2017

Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice (English)

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3 August 2017

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Amanda Posgai

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Clive Wasserfall

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Gerald Nepom

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Matthias von Herrath

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Matthias von Herrath

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Kevan Herold

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Ghanashyam Sarikonda

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Sowbarnika Sachithanantham

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Yulia Manenkova

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Tinalyn Kupfer

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Philip Bernstein

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Laura Straub

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Philippe P Pagni

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Darius Schneider

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Teresa Rodriguez Calvo

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Marilyne Coulombe

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Ronald G Gill

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Mark Atkinson

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Mario Ehlers

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Teodora Staeva

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Hideki Garren

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Lawrence Steinman

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Andrew C Chan

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6 February 2013

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3 August 2017

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Creative Commons Attribution 4.0 International

6 February 2013

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Transient depletion of B cells in young mice results in activation of regulatory T cells that inhibit development of autoimmune disease in adults

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Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study.

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The 'short' history of regulatory B cells

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7 July 2018

B cells in autoimmune diabetes

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7 July 2018

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

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7 July 2018

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

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Islet regeneration needed for overcoming autoimmune destruction - considerations on the pathogenesis of type 1 diabetes

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Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

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Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566105

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DNA immunization to prevent autoimmune diabetes

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Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice

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Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

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Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.

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B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice.

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1 reference

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10.1371/JOURNAL.PONE.0054712

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Europe PubMed Central

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3 August 2017

2013PLoSO...854712S

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