Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein. (Q34584004)

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22 December 2019

title

Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein (English)

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22 December 2019

1

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22 December 2019

author name string

Michal Segal

2

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22 December 2019

Roy Bekerman

3

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22 December 2019

Nobuhiko Tokuriki

4

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22 December 2019

Dan S Tawfik

5

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22 December 2019

language of work or name

English

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publication date

19 November 2006

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22 December 2019

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22 December 2019

volume

444

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22 December 2019

issue

7121

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22 December 2019

page(s)

929-932

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https://scigraph.springernature.com/pub.10.1038/nature05385

22 December 2019

exact match

0 references

cites work

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Interaction between directional epistasis and average mutational effects

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Sexual reproduction selects for robustness and negative epistasis in artificial gene networks

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Thermodynamic prediction of protein neutrality

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Genetic measurement of theory of epistatic effects.

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Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies

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Protein tolerance to random amino acid change

21 January 2018

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Deciphering the message in protein sequences: tolerance to amino acid substitutions

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Amino acid sequence determinants of beta-lactamase structure and activity

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Distributed robustness versus redundancy as causes of mutational robustness.

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Protein stability promotes evolvability

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The mutational meltdown in asexual populations

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The ubiquitin domain superfold: structure-based sequence alignments and characterization of binding epitopes

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Mutation-selection balance and the evolutionary advantage of sex and recombination

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inferred from DOI database lookup

7 January 2021

based on heuristic

Generation of large libraries of random mutants in Bacillus subtilis by PCR-based plasmid multimerization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05385

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE05385

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17122770%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

22 December 2019

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1 reference