The gift of Gab. (Q34593973)

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Language	Label	Description	Also known as
English	The gift of Gab.	scientific article

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

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Europe PubMed Central

The gift of Gab. (English)

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Europe PubMed Central

3 August 2017

author name string

Yan Liu

1

1 reference

Europe PubMed Central

3 August 2017

Larry R Rohrschneider

2

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Europe PubMed Central

3 August 2017

language of work or name

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publication date

1 March 2002

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Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

515

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Europe PubMed Central

3 August 2017

1-7

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Europe PubMed Central

3 August 2017

1-3

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Europe PubMed Central

3 August 2017

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Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors

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Immune signalling: SHP-2 docks at multiple ports

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

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Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

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Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

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Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

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Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and phosphatidylinositol 3'-kinase in myeloid cells

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Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells.

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Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase

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Gab3, a new DOS/Gab family member, facilitates macrophage differentiation

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Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

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DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

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In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling

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Raf functions downstream of Ras1 in the Sevenless signal transduction pathway

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The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction

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Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains.

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

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The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

1 reference

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

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A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis

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Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

1 reference

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Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

1 reference

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The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif

1 reference

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Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis

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New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

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Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

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Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

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Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro.

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Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor

1 reference

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Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

1 reference

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Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase

1 reference

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The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

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An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid.

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Essential role for Gab2 in the allergic response

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SH2 domains recognize specific phosphopeptide sequences

1 reference

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A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein

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Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

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1 reference

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Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

1 reference

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

1 reference

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Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1 reference

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Scatter factor/hepatocyte growth factor is essential for liver development

1 reference

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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1 reference

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Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

1 reference

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Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

1 reference

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Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro

1 reference

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The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.

1 reference

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Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

1 reference

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Recruitment of the protein-tyrosine phosphatase SHP-2 to the C-terminal tyrosine of the prolactin receptor and to the adaptor protein Gab2.

1 reference

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Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes

1 reference

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7 January 2021

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10.1016/S0014-5793(02)02425-0

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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