Chronically elevated glucose compromises myocardial mitochondrial DNA integrity by alteration of mitochondrial topoisomerase function (Q34597594)

3 August 2017

Chronically elevated glucose compromises myocardial mitochondrial DNA integrity by alteration of mitochondrial topoisomerase function (English)

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3 August 2017

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S Medikayala

1

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3 August 2017

B Piteo

series ordinal

2

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3 August 2017

X Zhao

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3

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3 August 2017

J G Edwards

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4

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3 August 2017

1 December 2010

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American Journal of Physiology - Cell Physiology

3 August 2017

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3 August 2017

300

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3 August 2017

2

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3 August 2017

C338-48

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Subcellular localization of Nox4 and regulation in diabetes

3 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Effects of magnesium and related divalent metal ions in topoisomerase structure and function.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

N-acetylcysteine prevents glucose/glucose oxidase-induced oxidative stress, mitochondrial damage and apoptosis in H9c2 cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Quantification of mitochondrial DNA (mtDNA) damage and error rates by real-time QPCR.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Association between mitochondrial DNA copy number, blood cell counts, and occupational benzene exposure

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Mitochondrial DNA repair in aging and disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Effects of dexrazoxane and amifostine on evolution of Doxorubicin cardiomyopathy in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Cardiac energy metabolism in obesity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Mitochondrial topoisomerases and alternative splicing of the human TOP1mt gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Fatty acid metabolism is enhanced in type 2 diabetic hearts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Bioenergetics of mitochondrial diseases associated with mtDNA mutations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Catalytic topoisomerase II inhibitors in cancer therapy.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Effect of DNA lesions on transcription elongation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Detection of changes in mitochondrial function during apoptosis by simultaneous staining with multiple fluorescent dyes and correlated multiparameter flow cytometry

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

The rate of mitochondrial mutagenesis is faster in mice than humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

There is substantial agreement among interspecies estimates of DNA repair activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

The unusual structures of the hot-regions flanking large-scale deletions in human mitochondrial DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Human aging is associated with stochastic somatic mutations of mitochondrial DNA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice

7 July 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Dexamethasone-associated toxicity during induction chemotherapy for childhood acute lymphoblastic leukemia is augmented by concurrent use of daunomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

A novel approach for organelle-specific DNA damage targeting reveals different susceptibility of mitochondrial DNA to the anticancer drugs camptothecin and topotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Determinants of subclinical diabetic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Accumulation of 8-hydroxy-2'-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Tissue-specific mtDNA lesions and radical-associated mitochondrial dysfunction in human hearts exposed to doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Oxidative stress-related alteration of the copy number of mitochondrial DNA in human leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

A truncated form of DNA topoisomerase IIβ associates with the mtDNA genome in mammalian mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Effects of diabetes on cardiac glycogen metabolism in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Palmitate induced mitochondrial deoxyribonucleic acid damage and apoptosis in l6 rat skeletal muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

High glucose-induced oxidative stress and mitochondrial dysfunction in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

Alteration in the copy number of mitochondrial DNA in leukocytes of patients with mitochondrial encephalomyopathies.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Clinical value of glycated hemoglobin and fructosamine in the long-term glycemic control of children with acute lymphoblastic leukemia.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043634

Cytofluorescence detection of adriamycin-mitochondria interactions in isolated, perfused rat heart

26 October 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00248.2010

The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity

21 January 2018

1 reference

12 December 2020

Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphoblastic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen

1 reference

12 December 2020

Absence of a Pyrimidine Dimer Repair Mechanism for Mitochondrial DNA in Mouse and Human Cells

1 reference

12 December 2020

Bis(2,6-dioxopiperazines), catalytic inhibitors of DNA topoisomerase II, as molecular probes, cardioprotectors and antitumor drugs

1 reference

12 December 2020

Mitochondrial genome instability and mtDNA depletion in human cancers

1 reference

12 December 2020

Myocyte death in streptozotocin-induced diabetes in rats in angiotensin II- dependent

1 reference

12 December 2020

Myocardial cell death in human diabetes

1 reference

12 December 2020

Hyperglycemia. A complication of chemotherapy in children

1 reference

12 December 2020

Spontaneous DNA damage stimulates topoisomerase II-mediated DNA cleavage

1 reference

12 December 2020

Early adaptations to training: upregulation of alpha-myosin heavy chain gene expression

1 reference

12 December 2020

10.1152/AJPCELL.00248.2010

Identifiers

DOI

1 reference

3 August 2017

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3 August 2017

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