"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening (Q34601049)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23438757%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening (English)

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24 February 2020

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6

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24 February 2020

author name string

Christopher J Schulze

1

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24 February 2020

Walter M Bray

2

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24 February 2020

Marcos H Woerhmann

3

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24 February 2020

Joshua Stuart

4

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24 February 2020

R Scott Lokey

5

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24 February 2020

publication date

1 February 2013

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24 February 2020

published in

Chemistry and Biology

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24 February 2020

volume

20

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24 February 2020

issue

2

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24 February 2020

page(s)

285-295

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Charting, navigating, and populating natural product chemical space for drug discovery

24 February 2020

cites work

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7 July 2018

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7 July 2018

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7 July 2018

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A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators

7 July 2018

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Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships

7 July 2018

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Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents.

7 July 2018

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Integrating high-content screening and ligand-target prediction to identify mechanism of action

7 July 2018

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Natural products as a screening resource

7 July 2018

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Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion

7 July 2018

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Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression

7 July 2018

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

7 July 2018

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Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7.

7 July 2018

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The evolving role of natural products in drug discovery

7 July 2018

1 reference

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Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG).

7 July 2018

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Small-molecule screening and profiling by using automated microscopy

7 July 2018

1 reference

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Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation

7 July 2018

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Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target

7 July 2018

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The Structure of Mithramycin Reinvestigated

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3584419

The effect of valinomycin on potassium and sodium permeability of HK and LK sheep red cells

7 July 2018

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Anthracycline metabolites of tetracenomycin C-nonproducing Streptomyces glaucescens mutants

7 July 2018

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Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells

7 July 2018

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The DNA sequence at echinomycin binding sites determines the structural changes induced by drug binding: NMR studies of echinomycin binding to [d(ACGTACGT)]2 and [d(TCGATCGA)]2.

7 July 2018

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A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

7 July 2018

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Interaction studies of resistomycin from Streptomyces aurantiacus AAA5 with calf thymus DNA and bovine serum albumin.

7 July 2018

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26 October 2018

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The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1.

26 October 2018

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26 October 2018

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26 October 2018

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The structure of resistomycin

26 October 2018

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12 December 2020

Structure revision of the antibiotic echinomycin

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Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity

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Molecular structure of heliomycin, an inhibitor of RNA synthesis

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Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers

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12 December 2020

Aureolic acid, a new antibiotic. I. Microbiologic studies

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1271/BBB1961.49.259

Identifiers

DOI

10.1016/J.CHEMBIOL.2012.12.007

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24 February 2020

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24 February 2020

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