Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha (Q34601360)

3 August 2017

Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha (English)

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3 August 2017

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4

Bernhard Brüne

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3 August 2017

Jie Zhou

1

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3 August 2017

Anastassios E Damdimopoulos

series ordinal

2

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3 August 2017

Giannis Spyrou

series ordinal

3

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3 August 2017

language of work or name

English

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publication date

12 January 2007

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Journal of Biological Chemistry

3 August 2017

9

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based on heuristic

inferred from page(s)

published in

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3 August 2017

282

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3 August 2017

10

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3 August 2017

7482-7490

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Targeting HIF-1 for cancer therapy

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Regulation of angiogenesis by hypoxia: role of the HIF system

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Functional integrity of nuclear factor kappaB, phosphatidylinositol 3'-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of

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Measurements of vector-derived neurotrophic factor and green fluorescent protein levels in the brain

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

21 January 2018

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Expression and growth-promoting effect of adult T-cell leukemia-derived factor. A human thioredoxin homologue in hepatocellular carcinoma

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Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system

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Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator

21 January 2018

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AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608289200

Thioredoxin-dependent redox regulation of p53-mediated p21 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608289200

Identification of redox/repair protein Ref-1 as a potent activator of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608289200

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

1 reference

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Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

21 January 2018

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Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase

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Mitochondrial free radical production and cell signaling

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

21 January 2018

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Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M608289200

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

21 January 2018

1 reference

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The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice

21 January 2018

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Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death

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Cloning and expression of a novel mammalian thioredoxin

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Glucocorticoid receptor isoforms in human hepatocarcinoma HepG2 and SaOS-2 osteosarcoma cells: presence of glucocorticoid receptor alpha in mitochondria and of glucocorticoid receptor beta in nucleoli.

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A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha.

21 January 2018

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Cellular response to oxidative stress: signaling for suicide and survival

21 January 2018

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Mitochondrial redox state regulates transcription of the nuclear-encoded mitochondrial protein manganese superoxide dismutase: a proposed adaptive response to mitochondrial redox imbalance.

21 January 2018

1 reference

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Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism

21 January 2018

1 reference

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

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Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity

21 January 2018

1 reference

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 January 2018

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Hypoxia-induced energy stress regulates mRNA translation and cell growth

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

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Cytokines and hormones in the regulation of hypoxia inducible factor-1alpha (HIF-1alpha).

21 January 2018

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PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

21 January 2018

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Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase

21 January 2018

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Downregulation of epidermal growth factor receptor signaling by singlet oxygen through activation of caspase-3 and protein phosphatases

21 January 2018

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Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

21 January 2018

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DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4.

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Physiological functions of thioredoxin and thioredoxin reductase

21 January 2018

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Induction of HIF-1alpha in response to hypoxia is instantaneous

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M608289200

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3 August 2017

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