PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR (Q24300018)

negative regulation of angiogenesis

1 reference

Promyelocytic leukemia

1 reference

Mechanistic target of rapamycin kinase

1 reference

author

Carlos Cordon-Cardo

7

0 references

Pier Paolo Pandolfi

10

0 references

Julie Teruya-Feldstein

6

0 references

Rosa Bernardi

Rosa Bernardi

1

0 references

Shahin Rafii

9

Shahin Rafii

0 references

Ilhem Guernah

2

Ilhem Guernah

0 references

Silvia Grisendi

4

Silvia Grisendi

0 references

Andrea Alimonti

5

Andrea Alimonti

0 references

author name string

David Jin

3

0 references

M Celeste Simon

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

8

0 references

language of work or name

English

0 references

publication date

17 August 2006

0 references

published in

Nature

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volume

442

0 references

page(s)

779-85

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issue

7104

0 references

cites work

1 reference

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

20 April 2017

1 reference

The role of PML in tumor suppression

20 April 2017

1 reference

PML is essential for multiple apoptotic pathways

20 April 2017

1 reference

Role of PML in cell growth and the retinoic acid pathway

20 April 2017

1 reference

Cytoplasmic PML function in TGF-beta signalling

20 April 2017

1 reference

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration

20 April 2017

1 reference

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

20 April 2017

1 reference

Targeting HIF-1 for cancer therapy

20 April 2017

1 reference

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

20 April 2017

1 reference

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

20 April 2017

1 reference

Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin

20 April 2017

1 reference

PML protein isoforms and the RBCC/TRIM motif

20 April 2017

1 reference

A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability

20 April 2017

1 reference

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

20 April 2017

1 reference

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

20 April 2017

1 reference

Role of nucleophosmin in embryonic development and tumorigenesis

20 April 2017

1 reference

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Vascular endothelial growth factor: basic science and clinical progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

HIF-1 and tumor progression: pathophysiology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Role of promyelocytic leukemia (PML) protein in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Identification of a tumour suppressor network opposing nuclear Akt function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Loss of the tumor suppressor PML in human cancers of multiple histologic origins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

PML nuclear bodies and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Mechanism for IL-1 beta-mediated neovascularization unmasked by IL-1 beta knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

How oxygen makes its presence felt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Hypoxia-induced energy stress regulates mRNA translation and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Ribosomal S6 kinase signaling and the control of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Restraining PI3K: mTOR signalling goes back to the membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

The expanding TOR signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Will mTOR inhibitors make it as cancer drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

mTOR-targeted therapy of cancer with rapamycin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

inferred from DOI database lookup

7 January 2021

based on heuristic

Lack of expression for the suppressor PML in human small cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029

inferred from DOI database lookup

7 January 2021

based on heuristic

When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05029