Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. (Q34602683)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300883%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells (English)

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21 January 2020

1

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21 January 2020

Scott H Kaufmann

series ordinal

3

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21 January 2020

author name string

Jann N Sarkaria

series ordinal

2

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21 January 2020

language of work or name

English

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publication date

7 February 2011

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21 January 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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21 January 2020

volume

108

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21 January 2020

issue

8

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21 January 2020

page(s)

3406-3411

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The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.

21 January 2020

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

7 July 2018

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

7 July 2018

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Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells

7 July 2018

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Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway

7 July 2018

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

7 July 2018

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Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

7 July 2018

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7 July 2018

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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

7 July 2018

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Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.

7 July 2018

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7 July 2018

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Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells

7 July 2018

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ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors

7 July 2018

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

7 July 2018

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Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma

7 July 2018

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53BP1: function and mechanisms of focal recruitment

7 July 2018

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Inhibition of repair of radiation-induced DNA damage enhances gene expression from replication-defective adenoviral vectors.

7 July 2018

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Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

7 July 2018

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The endless tale of non-homologous end-joining

7 July 2018

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Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

7 July 2018

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RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.

7 July 2018

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PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

7 July 2018

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Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

7 July 2018

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Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.

7 July 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

7 July 2018

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

7 July 2018

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

7 July 2018

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DNA end joining becomes less efficient and more error-prone during cellular senescence

7 July 2018

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

7 July 2018

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Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1

7 July 2018

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XRCC1 and DNA strand break repair

7 July 2018

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Biochemical evidence for Ku-independent backup pathways of NHEJ

7 July 2018

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Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

7 July 2018

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

7 July 2018

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Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

7 July 2018

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Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences

7 July 2018

1 reference

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Mutagenic activity of topoisomerase I inhibitors

7 July 2018

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Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.

7 July 2018

1 reference

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Recombinant ATM protein complements the cellular A-T phenotype

7 July 2018

1 reference

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Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas

7 July 2018

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Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1013715108

Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1013715108

Metaphase harvest and cytogenetic analysis of solid tumor cultures

21 January 2018

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12 December 2020

Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends

1 reference

12 December 2020

PARP inhibition in BRCA-mutated breast and ovarian cancers

1 reference

12 December 2020

Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1013715108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300883%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

0 references

1 reference

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21 January 2020

PubMed publication ID

21300883

1 reference