The limitations of calcineurin and mTOR inhibitors: new directions for immunosuppressive strategies (Q34604689)

3 August 2017

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title

The limitations of calcineurin and mTOR inhibitors: new directions for immunosuppressive strategies (English)

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3 August 2017

Kahan BD

1

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PubMed ID

11959221

3 August 2017

language of work or name

English

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publication date

1 February 2002

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Transplantation Proceedings

3 August 2017

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3 August 2017

34

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3 August 2017

1

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3 August 2017

130-133

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Protein serine/threonine phosphatases--new avenues for cell regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Regulation of the calmodulin-stimulated protein phosphatase, calcineurin

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Distinct tissue and cellular distribution of two major isoforms of calcineurin

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

T cell responses in calcineurin A alpha-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

1 reference

7 January 2021

Distribution of calcineurin A isoenzyme mRNAs in rat thymus and kidney

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Transcription factors of the NFAT family: regulation and function

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

The cyclosporin-sensitive transcription factor NFATp is expressed in several classes of cells in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells. Differential localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase C-coupled cell su

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Chronic cyclosporine nephropathy: the Achilles' heel of immunosuppressive therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Racial differences in renal transplantation after immunosuppression with tacrolimus versus cyclosporine. FK506 Kidney Transplant Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Rapamycin for immunosuppression in organ allografting.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Immunopharmacology of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Rapamycin resistance tied to defective regulation of p27Kip1.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I. Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21ras

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Regulation of eIF-4E BP1 phosphorylation by mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Role and relation of p70 S6 and extracellular signal-regulated kinases in the phenotypic changes of hypertrophy of cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in huma

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

The association of initiation factor 4F with poly(A)-binding protein is enhanced in serum-stimulated Xenopus kidney cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Synergistic effects of cyclosporine and rapamycin in a chronic nephrotoxicity model

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Use of anti-CD25 monoclonal antibody in combination with rapamycin to eliminate cyclosporine treatment during the induction phase of immunosuppression

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Lipids and progressive renal disease: the cardio-renal link

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

Cyclosporine and rapamycin affect protein kinase C induction of the intracellular activation signal, activator of DNA replication.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

The effect of rapamycin on kidney function in the Sprague-Dawley rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-1345%2801%2902702-6

7 January 2021

10.1016/S0041-1345(01)02702-6

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11959221