ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan. (Q34606492)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17255106%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

title

ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan (English)

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24 December 2019

2

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24 December 2019

Amanda Fosang

5

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24 December 2019

author name string

Charlotte J East

1

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24 December 2019

Suzanne B Golub

3

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24 December 2019

Fraser M Rogerson

4

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24 December 2019

language of work or name

English

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publication date

25 January 2007

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Journal of Biological Chemistry

24 December 2019

published in

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24 December 2019

volume

282

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24 December 2019

issue

12

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24 December 2019

page(s)

8632-8640

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Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis

24 December 2019

cites work

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N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

21 January 2018

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Mechanism of catabolism of aggrecan by articular cartilage

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The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

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Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

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Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

21 January 2018

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ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan

21 January 2018

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ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage

21 January 2018

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Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1

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ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

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Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

21 January 2018

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Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).

21 January 2018

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Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i

21 January 2018

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Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

21 January 2018

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Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids

21 January 2018

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A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures.

21 January 2018

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A new mathematical model for relative quantification in real-time RT-PCR

21 January 2018

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Adamts-1 is essential for the development and function of the urogenital system

21 January 2018

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ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function

21 January 2018

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Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

21 January 2018

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ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures

21 January 2018

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Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.

21 January 2018

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Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine

21 January 2018

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Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

21 January 2018

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Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation

21 January 2018

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Variations in aggrecan structure modulate its susceptibility to aggrecanases

21 January 2018

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Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.

21 January 2018

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Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development

21 January 2018

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Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan

21 January 2018

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Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

21 January 2018

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Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

21 January 2018

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The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism

21 January 2018

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Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism

21 January 2018

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Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).

21 January 2018

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Cartilage degradation independent of MMP/aggrecanases

21 January 2018

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