Humanized mice in translational biomedical research (Q34607151)

3 August 2017

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title

Humanized mice in translational biomedical research (English)

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3 August 2017

Leonard D Shultz

1

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PubMed ID

17259968

3 August 2017

Fumihiko Ishikawa

series ordinal

2

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PubMed ID

17259968

3 August 2017

Dale L Greiner

series ordinal

3

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3 August 2017

1 February 2007

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Nature Reviews Immunology

3 August 2017

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3 August 2017

7

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3 August 2017

118-130

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3 August 2017

2

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A severe combined immunodeficiency mutation in the mouse

3 August 2017

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Transfer of a functional human immune system to mice with severe combined immunodeficiency

31 March 2020

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The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

31 March 2020

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Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice

31 March 2020

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SCID mouse models of human stem cell engraftment

31 March 2020

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The scid mutation in mice causes a general defect in DNA repair

31 March 2020

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RAG-1-deficient mice have no mature B and T lymphocytes

31 March 2020

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

31 March 2020

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High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice

31 March 2020

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NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells

31 March 2020

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Development of a human adaptive immune system in cord blood cell-transplanted mice.

31 March 2020

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Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells

31 March 2020

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Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice

31 March 2020

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The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID

31 March 2020

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Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

31 March 2020

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Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

31 March 2020

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PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice

31 March 2020

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A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow

31 March 2020

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Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells.

31 March 2020

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Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

31 March 2020

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Retention and multilineage expression of human hematopoietic stem cells in human-sheep chimeras

31 March 2020

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Studies on the development of human acute myeloid leukaemia xenografts in immune-deprived mice: comparison with cells in short-term culture

31 March 2020

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Inability of intravenously injected monocellular suspensions of human bone marrow to establish in the nude mouse

31 March 2020

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NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells

31 March 2020

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Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells

31 March 2020

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Engraftment kinetics of human cord blood and murine fetal liver stem cells following in utero transplantation into immunodeficient mice

31 March 2020

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Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.

31 March 2020

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Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors

31 March 2020

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In vivo repopulation ability of genetically corrected bone marrow cells from Fanconi anemia patients

31 March 2020

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Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy

31 March 2020

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Human fetal, cord blood, and adult lymphocyte progenitors have similar potential for generating B cells with a diverse immunoglobulin repertoire

31 March 2020

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Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice

31 March 2020

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Experimental models to study development and function of the human immune system in vivo

31 March 2020

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Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/gammac(null) (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells

31 March 2020

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Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice

31 March 2020

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Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice

31 March 2020

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Intra-thymic/splenic engraftment of human T cells in HLA-DR1 transgenic NOD/scid mice

31 March 2020

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Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes

31 March 2020

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Generation of a synthetic lymphoid tissue-like organoid in mice

31 March 2020

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Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.

31 March 2020

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SCID-hu-PBL: a model for making human antibodies?

31 March 2020

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The huPBL-SCID mouse as a means to examine human immune function in vivo

31 March 2020

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NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment

31 March 2020

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Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras

31 March 2020

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Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies.

31 March 2020

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Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse

31 March 2020

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A role for BLyS in the activation of innate immune cells

31 March 2020

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Homeostatic proliferation of B cells

31 March 2020

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Evaluation of gp160 vaccinees in the hu-PBL-SCID mouse model

31 March 2020

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Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice

31 March 2020

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A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice

31 March 2020

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In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens

31 March 2020

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The SCID-hu mouse: a small animal model for HIV infection and pathogenesis

31 March 2020

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Breaking the species barrier: use of SCID mouse-human chimeras for the study of human infectious diseases

31 March 2020

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Dengue Fever in Humanized NOD/SCID Mice

31 March 2020

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Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein-Barr virus

31 March 2020

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Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application

31 March 2020

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The immunodeficient scid mouse as a model for human lymphatic filariasis

31 March 2020

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Passive serum therapy with polyclonal antibodies against Mycobacterium tuberculosis protects against post-chemotherapy relapse of tuberculosis infection in SCID mice

31 March 2020

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Liver-stage development of Plasmodium falciparum, in a humanized mouse model

31 March 2020

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The course of infections and pathology in immunomodulated NOD/LtSz-SCID mice inoculated with Plasmodium falciparum laboratory lines and clinical isolates.

31 March 2020

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Humanized mice: are we there yet?

31 March 2020

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Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice

31 March 2020

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Viral pathogenesis in hu-PBL-SCID mice

31 March 2020

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A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity

31 March 2020

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Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice

31 March 2020

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HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model

31 March 2020

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Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses

31 March 2020

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Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID)

31 March 2020

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Characteristics of long-term human thyroid peroxidase autoantibody secretion in scid mice transplanted with lymphocytes from patients with autoimmune thyroiditis

31 March 2020

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Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritis

31 March 2020

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Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients

31 March 2020

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Humanized animal models for autoimmune diseases

31 March 2020

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Humanized mouse models for organ-specific autoimmune diseases

31 March 2020

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HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes

31 March 2020

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The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model

31 March 2020

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Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice

31 March 2020

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High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model

31 March 2020

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Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells

31 March 2020

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Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

31 March 2020

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Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice.

31 March 2020

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Xenotransplantation of human lymphoid malignancies is optimized in mice with multiple immunologic defects

31 March 2020

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Biology of normal and acute myeloid leukemia stem cells

31 March 2020

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Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice.

31 March 2020

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Engraftment of NOD/SCID/gammac(null) mice with multilineage neoplastic cells from patients with juvenile myelomonocytic leukaemia

31 March 2020

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Applying the principles of stem-cell biology to cancer

31 March 2020

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Stem cells, cancer, and cancer stem cells

31 March 2020

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

31 March 2020

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Prospective identification of tumorigenic breast cancer cells

31 March 2020

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

31 March 2020

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Identification of human brain tumour initiating cells

31 March 2020

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Angiostatin induces and sustains dormancy of human primary tumors in mice

31 March 2020

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Activated natural killer cells from patients with acute myeloid leukemia are cytotoxic against autologous leukemic blasts in NOD/SCID mice.

31 March 2020

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The anti-CD20 antibody rituximab augments the immunospecific therapeutic effectiveness of an anti-CD19 immunotoxin directed against human B-cell lymphoma.

31 March 2020

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Soluble interleukin-13Ralpha2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo.

31 March 2020

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Rapid Tumor Formation of Human T-Cell Leukemia Virus Type 1-Infected Cell Lines in Novel NOD-SCID/γcnullMice: Suppression by an Inhibitor against NF-κB

31 March 2020

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A novel NF-kappaB inhibitor DHMEQ selectively targets constitutive NF-kappaB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo

31 March 2020

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BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice

31 March 2020

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Therapeutic potential of adult stem cells

31 March 2020

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From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research

31 March 2020

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Human umbilical cord blood as a source of transplantable hepatic progenitor cells

31 March 2020

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Near completely humanized liver in mice shows human-type metabolic responses to drugs

31 March 2020

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Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion.

31 March 2020

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Umbilical cord blood cell transplantation for myocardial regeneration

31 March 2020

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Human circulating AC133(+) stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle

31 March 2020

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Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cells

31 March 2020

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Vasculogenic potential of long term repopulating cord blood progenitors.

31 March 2020

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7. Transplantation of undifferentiated, bone marrow-derived stem cells

31 March 2020

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Bone marrow-derived stem cells initiate pancreatic regeneration.

31 March 2020

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Human cord blood--derived cells generate insulin-producing cells in vivo.

31 March 2020

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Transplanted bone marrow regenerates liver by cell fusion

31 March 2020

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Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34-positive cells into cardiomyocytes in vivo

31 March 2020

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Stem cell therapy for ischemic heart disease: beginning or end of the road?

31 March 2020

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Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells.

31 March 2020

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Growth of teratomas derived from human pluripotent stem cells is influenced by the graft site.

31 March 2020

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Differentiation of human embryonic stem cells after transplantation in immune-deficient mice

31 March 2020

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Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression

31 March 2020

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Hematopoietic Engraftment of Human Embryonic Stem Cell-Derived Cells Is Regulated by Recipient Innate Immunity

31 March 2020

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T lineage differentiation from human embryonic stem cells

31 March 2020

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The science and ethics of making part-human animals in stem cell biology

31 March 2020

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Interactions between human mesenchymal stem cells and natural killer cells

31 March 2020

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‘Nude’, a new hairless gene with pleiotropic effects in the mouse

31 March 2020

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Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation

31 March 2020

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NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration

31 March 2020

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Human immunodeficiency virus infection of human cells transplanted to severe combined immunodeficient mice.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23

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inferred from DOI database lookup

7 January 2021

based on heuristic

Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. The role of SDF-1/CXCR4 interactions

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI2017

1 reference

3 August 2017

1 reference

PubMed ID

17259968