The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. (Q34612189)

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28 December 2019

title

The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas (English)

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28 December 2019

6

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28 December 2019

Keith D. Robertson

12

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28 December 2019

Sun Young Rha

13

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28 December 2019

Qian Tao

15

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28 December 2019

author name string

Stephen L Chan

1

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28 December 2019

Yan Cui

2

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28 December 2019

Andrew van Hasselt

3

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28 December 2019

Hongyu Li

4

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28 December 2019

Gopesh Srivastava

5

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28 December 2019

Ka M Ng

7

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28 December 2019

Yajun Wang

8

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28 December 2019

Kwan Y Lee

9

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28 December 2019

George S W Tsao

10

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28 December 2019

Sheng Zhong

11

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28 December 2019

Anthony T C Chan

14

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28 December 2019

publication date

26 March 2007

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28 December 2019

published in

Laboratory Investigation

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28 December 2019

volume

87

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28 December 2019

issue

7

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28 December 2019

page(s)

644-650

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https://scigraph.springernature.com/pub.10.1038/labinvest.3700547

28 December 2019

exact match

0 references

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

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GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

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Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis.

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Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer

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Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.

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WIF1, a component of the Wnt pathway, is down‐regulated in prostate, breast, lung, and bladder cancer

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Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer.

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7 January 2021

Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma

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7 January 2021

Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays.

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Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes.

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7 January 2021

Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation

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The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors.

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7 January 2021

The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma.

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17384664%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 December 2019

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