Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice (Q34615377)

3 August 2017

title

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice (English)

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3 August 2017

11

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3 August 2017

Ghazala Begum

12

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Mark Smith

Mark A Smith

2

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Marc Claret

Marc Claret

1

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Amanda Heslegrave

Amanda Heslegrave

6

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Claude Knauf

Claude Knauf

3

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Rachel L. Batterham

Rachel L Batterham

17

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Dominic J Withers

Dominic J Withers

23

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Michael L Ashford

Michael L Ashford

21

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David Carling

David Carling

22

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Anne White

Anne White

13

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author name string

Hind Al-Qassab

4

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3 August 2017

Angela Woods

5

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3 August 2017

Kaisa Piipari

7

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3 August 2017

Julian J Emmanuel

8

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3 August 2017

André Colom

9

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3 August 2017

Philippe Valet

10

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3 August 2017

Phillip Mucket

14

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3 August 2017

Marco Peters

15

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3 August 2017

Keiko Mizuno

16

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3 August 2017

K Peter Giese

18

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3 August 2017

Alan Ashworth

19

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3 August 2017

Remy Burcelin

20

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3 August 2017

language of work or name

English

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publication date

24 January 2011

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3 August 2017

number of pages

11

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based on heuristic

inferred from page(s)

published in

Diabetes

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3 August 2017

volume

60

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3 August 2017

issue

3

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3 August 2017

page(s)

735-745

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

3 August 2017

copyright license

start time

30 August 2021

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

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Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility

7 July 2018

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Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

7 July 2018

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The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

7 July 2018

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Neuropeptide processing and its impact on melanocortin pathways

7 July 2018

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LKB1/STRAD promotes axon initiation during neuronal polarization.

7 July 2018

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LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons

7 July 2018

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Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances

7 July 2018

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Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3

7 July 2018

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7 July 2018

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AMP-activated protein kinase signaling in metabolic regulation

7 July 2018

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Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

7 July 2018

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

7 July 2018

1 reference

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Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

7 July 2018

1 reference

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

7 July 2018

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

7 July 2018

1 reference

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Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

7 July 2018

1 reference

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The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

7 July 2018

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PI3K integrates the action of insulin and leptin on hypothalamic neurons

7 July 2018

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Mammalian SAD kinases are required for neuronal polarization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

7 July 2018

1 reference

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Essential role of PDK1 in regulating cell size and development in mice

7 July 2018

1 reference

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Central melanocortin receptors regulate insulin action

7 July 2018

1 reference

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Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Neuronal glucose sensing: still a physiological orphan?

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Divergence of melanocortin pathways in the control of food intake and energy expenditure

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Melanocortin-independent effects of leptin on hepatic glucose fluxes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

Loss of Ca2+/Calmodulin Kinase Kinase β Affects the Formation of Some, But Not All, Types of Hippocampus-Dependent Long-Term Memory

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

The central melanocortin system can directly regulate serum insulin levels

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046834

26 October 2018

Identifiers

DOI

10.2337/DB10-1055

1 reference

3 August 2017

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3 August 2017

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