Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase (Q34619502)

3 August 2017

title

Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase (English)

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3 August 2017

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2

Peter Wipf

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3 August 2017

1

Garth Powis

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3 August 2017

Stephen M Lynch

3

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3 August 2017

Anne Birmingham

series ordinal

4

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3 August 2017

D Lynn Kirkpatrick

series ordinal

5

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3 August 2017

publication date

1 March 2006

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Molecular Cancer Therapeutics

3 August 2017

published in

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3 August 2017

volume

5

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3 August 2017

issue

3

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3 August 2017

page(s)

630-636

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Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system

3 August 2017

cites work

1 reference

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7 July 2018

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Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

7 July 2018

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7 July 2018

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Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development

7 July 2018

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7 July 2018

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7 July 2018

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Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity

7 July 2018

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7 July 2018

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How thioredoxin can reduce a buried disulphide bond

7 July 2018

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Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Increased thioredoxin-1 inhibits SSAT expression in MCF-7 human breast cancer cells

7 July 2018

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The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

7 July 2018

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Properties and biological activities of thioredoxins

7 July 2018

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Thioredoxin reductase as a pathophysiological factor and drug target

7 July 2018

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7 July 2018

Thioredoxin reductase

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Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases

7 July 2018

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7 July 2018

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7 July 2018

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AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

7 July 2018

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Purification of human thioredoxin reductase: properties and characterization by absorption and circular dichroism spectroscopy.

7 July 2018

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Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin.

7 July 2018

1 reference

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The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors

7 July 2018

1 reference

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Coexpression of adult T-cell leukemia-derived factor, a human thioredoxin homologue, and human papillomavirus DNA in neoplastic cervical squamous epithelium.

7 July 2018

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Expression and growth-promoting effect of adult T-cell leukemia-derived factor. A human thioredoxin homologue in hepatocellular carcinoma

7 July 2018

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Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.

7 July 2018

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Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival

26 October 2018

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The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.

26 October 2018

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Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin

26 October 2018

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Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer.

26 October 2018

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Rat liver thioredoxin and thioredoxin reductase: purification and characterization

26 October 2018

1 reference

12 December 2020

Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin

1 reference

12 December 2020

Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro

1 reference

12 December 2020

Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia

1 reference

12 December 2020

Cellular thioredoxin reductase activity is regulated by selenium

1 reference

12 December 2020

Effect of selenium on rat thioredoxin reductase activity: increase by supranutritional selenium and decrease by selenium deficiency

1 reference

12 December 2020

Thioredoxin, a putative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival

1 reference

12 December 2020

Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer

1 reference

12 December 2020

10.1158/1535-7163.MCT-05-0487

Identifiers

DOI

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3 August 2017

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3 August 2017

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