Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate (Q34623352)

3 August 2017

title

Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate (English)

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3 August 2017

main subject

transmembrane protein

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author name string

Rosanna P Baker

1

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3 August 2017

Keith Young

2

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3 August 2017

Liang Feng

3

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3 August 2017

Yigong Shi

4

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3 August 2017

Sinisa Urban

5

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3 August 2017

language of work or name

English

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publication date

26 April 2007

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Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

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3 August 2017

volume

104

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3 August 2017

issue

20

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3 August 2017

page(s)

8257-8262

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Open-cap conformation of intramembrane protease GlpG

3 August 2017

cites work

1 reference

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The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis

7 July 2018

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Structural basis for intramembrane proteolysis by rhomboid serine proteases

7 July 2018

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Rhomboid proteins: conserved membrane proteases with divergent biological functions

7 July 2018

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Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry

7 July 2018

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Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs

7 July 2018

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TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

7 July 2018

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Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

7 July 2018

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Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity

7 July 2018

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RseP (YaeL), an Escherichia coli RIP protease, cleaves transmembrane sequences

7 July 2018

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7 July 2018

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Purification and characterization of the human gamma-secretase complex

7 July 2018

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X-ray structure of a protein-conducting channel

7 July 2018

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Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain

7 July 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

7 July 2018

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7 July 2018

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The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers

7 July 2018

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Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

7 July 2018

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Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids

7 July 2018

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A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes.

7 July 2018

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Identification of signal peptide peptidase, a presenilin-type aspartic protease

7 July 2018

1 reference

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Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

7 July 2018

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Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

7 July 2018

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7 July 2018

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

7 July 2018

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

7 July 2018

1 reference

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Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

7 July 2018

1 reference

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Reconstitution of gamma-secretase activity

7 July 2018

1 reference

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Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700814104

Crystal structure of a rhomboid family intramembrane protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0700814104

Gamma-secretase: proteasome of the membrane?

21 January 2018

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Designed Helical Peptides Inhibit an Intramembrane Protease

21 January 2018

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Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

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Three-dimensional structure of the γ-secretase complex

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1073/PNAS.0700814104

1 reference

3 August 2017

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3 August 2017

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