The role of presenilin cofactors in the gamma-secretase complex (Q40661006)

22 September 2017

The role of presenilin cofactors in the gamma-secretase complex (English)

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Presenilin enhancer, gamma-secretase subunit

22 September 2017

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amyloid-beta formation

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Presenilin enhancer gamma secretase subunit

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Nicastrin Dmel_CG7012

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Presenilin enhancer Dmel_CG33198

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Presenilin Dmel_CG18803

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Anterior pharynx defective 1 Dmel_CG2855

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author

Taisuke Tomita

2

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22 September 2017

Nobumasa Takasugi

1

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22 September 2017

Ikuo Hayashi

3

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22 September 2017

Makiko Tsuruoka

4

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22 September 2017

Manabu Niimura

5

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22 September 2017

Yasuko Takahashi

6

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22 September 2017

Gopal Thinakaran

7

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22 September 2017

Takeshi Iwatsubo

8

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22 September 2017

language of work or name

English

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publication date

16 March 2003

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22 September 2017

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22 September 2017

422

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22 September 2017

438-441

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22 September 2017

6930

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https://scigraph.springernature.com/pub.10.1038/nature01506

22 September 2017

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cites work

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Newly established cell lines from Drosophila larval CNS express neural specific characteristics

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Intramembrane proteolysis controls diverse signalling pathways throughout evolution

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

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https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01506

7 January 2021

Identifiers

DOI

10.1038/NATURE01506

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Dimensions Publication ID

22 September 2017

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