Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid tumors (Q34625315)

3 August 2017

title

Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid tumors (English)

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3 August 2017

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1

Pasi A Jänne

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3 August 2017

3

D Ross Camidge

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3 August 2017

14

Jan H M Schellens

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3 August 2017

David S Boss

2

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3 August 2017

Carolyn D Britten

4

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3 August 2017

Jeffrey A Engelman

5

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3 August 2017

Edward B Garon

6

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3 August 2017

Feng Guo

7

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3 August 2017

Steven Wong

8

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3 August 2017

Jane Liang

9

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3 August 2017

Stephen Letrent

10

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Robert Millham

11

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3 August 2017

Ian Taylor

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3 August 2017

S Gail Eckhardt

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3 August 2017

language of work or name

English

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publication date

10 January 2011

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3 August 2017

published in

Clinical Cancer Research

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3 August 2017

volume

17

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3 August 2017

issue

5

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3 August 2017

page(s)

1131-1139

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Screening for epidermal growth factor receptor mutations in lung cancer

3 August 2017

cites work

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Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

7 July 2018

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7 July 2018

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7 July 2018

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

7 July 2018

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PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib

7 July 2018

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7 July 2018

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7 July 2018

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Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

7 July 2018

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Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

7 July 2018

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Lung cancer: intragenic ERBB2 kinase mutations in tumours

7 July 2018

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

7 July 2018

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Untangling the ErbB signalling network

7 July 2018

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

7 July 2018

1 reference

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Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

7 July 2018

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A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors

7 July 2018

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Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response

26 October 2018

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Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer.

26 October 2018

1 reference

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Administration of CI-1033, an irreversible pan-erbB tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase I pharmacokinetic and food effect study

26 October 2018

1 reference

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Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21220471

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1078-0432.CCR-10-1220

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3 August 2017

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3 August 2017

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