The Wnt signaling pathway: implications for therapy in osteosarcoma (Q34632285)

3 August 2017

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title

The Wnt signaling pathway: implications for therapy in osteosarcoma (English)

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3 August 2017

Peter McQueen

1

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3 August 2017

Samia Ghaffar

2

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3 August 2017

Yi Guo

3

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3 August 2017

Elyssa M Rubin

4

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3 August 2017

Xiaolin Zi

5

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3 August 2017

Bang H Hoang

6

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3 August 2017

1 August 2011

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Expert Review of Anticancer Therapy

3 August 2017

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3 August 2017

11

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3 August 2017

8

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3 August 2017

1223-1232

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Osteosarcoma: basic science and clinical implications

3 August 2017

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Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways.

21 January 2018

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Wnt signaling and human diseases: what are the therapeutic implications?

21 January 2018

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Mining the Wnt pathway for cancer therapeutics

21 January 2018

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21 January 2018

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

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High bone mass in mice expressing a mutant LRP5 gene

21 January 2018

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The Wnt signaling pathway and bone metabolism

21 January 2018

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Regulation of bone mass by Wnt signaling

21 January 2018

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Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma

21 January 2018

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Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling

21 January 2018

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Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma

21 January 2018

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Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma

21 January 2018

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Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

21 January 2018

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Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

21 January 2018

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Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines

21 January 2018

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Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer

21 January 2018

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Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma

21 January 2018

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Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer.

21 January 2018

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Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray

21 January 2018

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Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma

21 January 2018

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Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling

21 January 2018

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The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo

21 January 2018

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Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway

21 January 2018

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Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling

21 January 2018

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Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells

21 January 2018

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Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model

21 January 2018

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Towards an integrated view of Wnt signaling in development

21 January 2018

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Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

21 January 2018

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The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway

21 January 2018

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Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma

21 January 2018

1 reference

Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas

21 January 2018

1 reference

Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma

21 January 2018

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MET overexpression turns human primary osteoblasts into osteosarcomas.

21 January 2018

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Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer

21 January 2018

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Investigating the potential of bevacizumab in other indications: metastatic renal cell, non-small cell lung, pancreatic and breast cancer

21 January 2018

1 reference

Small molecules with EGFR-TK inhibitor activity

21 January 2018

1 reference

Targeting the HGF/Met signalling pathway in cancer.

21 January 2018

1 reference

A novel small molecule Met inhibitor, PF2362376, exhibits biological activity against osteosarcoma.

21 January 2018

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The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines

21 January 2018

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Stemming cancer: functional genomics of cancer stem cells in solid tumors

21 January 2018

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Stem-like cells in bone sarcomas: implications for tumorigenesis

21 January 2018

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Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity

21 January 2018

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Detection and characterization of CD133+ cancer stem cells in human solid tumours

21 January 2018

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Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma

21 January 2018

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Identification of human brain tumour initiating cells

21 January 2018

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Identification and expansion of human colon-cancer-initiating cells

21 January 2018

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Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance

21 January 2018

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

21 January 2018

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Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells

21 January 2018

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Targeting Wnt signaling: can we safely eradicate cancer stem cells?

21 January 2018

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PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac

21 January 2018

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A randomized trial of aspirin to prevent colorectal adenomas

21 January 2018

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Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention

21 January 2018

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A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer

21 January 2018

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Enhanced anticancer activity of glutamate prodrugs of all-trans retinoic acid

21 January 2018

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Trans-repression of beta-catenin activity by nuclear receptors

21 January 2018

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Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells.

21 January 2018

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Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1

21 January 2018

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Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells

21 January 2018

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Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenström's macroglobulinemia

21 January 2018

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Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

21 January 2018

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Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

21 January 2018

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2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer

21 January 2018

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Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

21 January 2018

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Identification of a specific inhibitor of the dishevelled PDZ domain

21 January 2018

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An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

21 January 2018

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A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

21 January 2018

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Canonical Wnt signaling: high-throughput RNAi widens the path

21 January 2018

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Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERA.11.94

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3 August 2017

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