Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. (Q37269189)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19383605%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled (English)

1 reference

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26 January 2020

12

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26 January 2020

author name string

David Grandy

1

1 reference

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26 January 2020

Jufang Shan

2

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26 January 2020

Xinxin Zhang

3

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26 January 2020

Sujata Rao

4

1 reference

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26 January 2020

Shailaja Akunuru

5

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26 January 2020

Hongyan Li

6

1 reference

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26 January 2020

Yanhui Zhang

7

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26 January 2020

Ivan Alpatov

8

1 reference

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26 January 2020

Xin A Zhang

9

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26 January 2020

Richard A Lang

10

1 reference

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26 January 2020

De-Li Shi

11

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26 January 2020

language of work or name

English

0 references

publication date

21 April 2009

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Journal of Biological Chemistry

26 January 2020

number of pages

8

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based on heuristic

inferred from page(s)

published in

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26 January 2020

volume

284

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26 January 2020

issue

24

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26 January 2020

page(s)

16256-16263

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Identification of tripeptides recognized by the PDZ domain of Dishevelled

26 January 2020

cites work

1 reference

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6 September 2017

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6 September 2017

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Prediction of protein-ligand interactions. Docking and scoring: successes and gaps

6 September 2017

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Identification of a specific inhibitor of the dishevelled PDZ domain

6 September 2017

1 reference

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The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

6 September 2017

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WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

6 September 2017

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Virtual screening of chemical libraries

6 September 2017

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6 September 2017

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6 September 2017

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Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain

6 September 2017

1 reference

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Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

6 September 2017

1 reference

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Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

6 September 2017

1 reference

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WIF1, a component of the Wnt pathway, is down‐regulated in prostate, breast, lung, and bladder cancer

6 September 2017

1 reference

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Caught up in a Wnt storm: Wnt signaling in cancer

6 September 2017

1 reference

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Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation

6 September 2017

1 reference

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Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

6 September 2017

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Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling

6 September 2017

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Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement

6 September 2017

1 reference

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Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway

6 September 2017

1 reference

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The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling

6 September 2017

1 reference

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Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.

6 September 2017

1 reference

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Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking

6 September 2017

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Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

6 September 2017

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Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

6 September 2017

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cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas

6 September 2017

1 reference

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A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus

6 September 2017

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Development and validation of a genetic algorithm for flexible docking

6 September 2017

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

6 September 2017

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

6 September 2017

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The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure

6 September 2017

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A fast and efficient method to generate biologically relevant conformations

6 September 2017

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A geometric approach to macromolecule-ligand interactions

6 September 2017

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The computer program LUDI: a new method for the de novo design of enzyme inhibitors

6 September 2017

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

6 September 2017

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Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness

6 September 2017

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Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression

14 September 2017

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Transformation by Wnt family proteins correlates with regulation of beta-catenin

14 September 2017

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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

28 September 2017

1 reference

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Upregulation and overexpression of DVL1, the human counterpart of the Drosophila dishevelled gene, in prostate cancer.

26 June 2018

1 reference

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Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin

3 September 2018

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Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers.

3 September 2018

1 reference

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A general and fast scoring function for protein-ligand interactions: a simplified potential approach.

3 September 2018

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Protein recognition by NMR

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19383605

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.009647

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19383605%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19383605%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference