The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes (Q34647086)

3 August 2017

title

The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes (English)

1 reference

3 August 2017

3

Jeffrey A Bluestone

1 reference

3 August 2017

Melanie Stumpf

1

1 reference

3 August 2017

Xuyu Zhou

series ordinal

2

1 reference

3 August 2017

language of work or name

English

0 references

publication date

4 January 2013

1 reference

3 August 2017

published in

Journal of Immunology

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3 August 2017

volume

190

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3 August 2017

issue

3

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3 August 2017

page(s)

961-969

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Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells

3 August 2017

cites work

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The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function

7 July 2018

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7 July 2018

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7 July 2018

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Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

7 July 2018

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Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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CTLA-4: a key regulatory point in the control of autoimmune disease

7 July 2018

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7 July 2018

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7 July 2018

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A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene

7 July 2018

1 reference

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CTLA-4 (CD152) and its involvement in autoimmune disease

7 July 2018

1 reference

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CTLA4 gene polymorphism and autoimmunity

7 July 2018

1 reference

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Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.

7 July 2018

1 reference

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

7 July 2018

1 reference

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CTLA-4 and tolerance: the biochemical point of view

7 July 2018

1 reference

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

7 July 2018

1 reference

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Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

7 July 2018

1 reference

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Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A

7 July 2018

1 reference

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Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells

7 July 2018

1 reference

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The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

7 July 2018

1 reference

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.

7 July 2018

1 reference

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Molecular basis of T cell inactivation by CTLA-4

7 July 2018

1 reference

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Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

CTLA-4 ligation blocks CD28-dependent T cell activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Regulation of CTLA-4 expression during T cell activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Cd28 and Ctla-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome 1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

CTLA-4 and CD28: similar proteins, neighbouring genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation

7 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

26 October 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

B7-independent inhibition of T cells by CTLA-4.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568535

Transgenic mice with hematopoietic and lymphoid specific expression of Cre

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23293354

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Following a diabetogenic T cell from genesis through pathogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23293354

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.1201362

1 reference

3 August 2017

1 reference

3 August 2017

1 reference