The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function (Q35063250)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function (English)

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1 February 2020

0 references

2

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1 February 2020

S Kissler

6

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1 February 2020

author name string

Kay D Gerold

1

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1 February 2020

Daniel B Rainbow

3

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1 February 2020

Linda S Wicker

5

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1 February 2020

Alma Zernecke

4

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1 February 2020

language of work or name

English

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publication date

20 May 2011

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1 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

60

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1 February 2020

issue

7

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1 February 2020

page(s)

1955-1963

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

1 February 2020

copyright license

start time

27 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

8 July 2018

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Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

8 July 2018

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Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

8 July 2018

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REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

8 July 2018

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

8 July 2018

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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

8 July 2018

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8 July 2018

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CTLA-4 control over Foxp3+ regulatory T cell function

8 July 2018

1 reference

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Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

8 July 2018

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8 July 2018

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

8 July 2018

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Reversal of the TCR stop signal by CTLA-4

8 July 2018

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A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

8 July 2018

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The NOD mouse: a model of immune dysregulation

8 July 2018

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Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

8 July 2018

1 reference

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435

Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases

8 July 2018

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

8 July 2018

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Structure of murine CTLA-4 and its role in modulating T cell responsiveness

8 July 2018

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

8 July 2018

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

8 July 2018

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A native soluble form of CTLA-4

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435

A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

8 July 2018

1 reference

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B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.

8 July 2018

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CTLA-4 ligation blocks CD28-dependent T cell activation

8 July 2018

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CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

8 July 2018

1 reference

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

8 July 2018

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

8 July 2018

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In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.

8 July 2018

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Association of CTLA4 polymorphism with regulatory T cell frequency.

27 September 2018

1 reference

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Modulation of tryptophan catabolism by regulatory T cells.

27 September 2018

1 reference

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The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435

Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435

CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21602513

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB11-0130

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

21602513

1 reference