Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency (Q34649087)

3 August 2017

title

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency (English)

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3 August 2017

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7

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Pierre Corvol

Marie-Laure Raffin-Sanson

9

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4

Marie-Laure Raffin-Sanson

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Anne White

Anne White

15

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Stephen O'Rahilly

Stephen O'Rahilly

22

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Mehul T Dattani

16

Mehul T Dattani

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3 August 2017

2

John W M Creemers

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3 August 2017

Robert S Jackson

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Andrea Varro

5

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3 August 2017

Graham J Dockray

6

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3 August 2017

Patricia L Brubaker

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3 August 2017

Kenneth S Polonsky

10

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3 August 2017

Diane Ostrega

11

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3 August 2017

Kenneth L Becker

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3 August 2017

Xavier Bertagna

13

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3 August 2017

John C Hutton

14

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Khalid Hussain

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Stephen J Middleton

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Thomasina M Nicole

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Peter J Milla

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Keith J Lindley

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3 August 2017

language of work or name

English

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publication date

1 November 2003

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Journal of Clinical Investigation

3 August 2017

published in

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3 August 2017

volume

112

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3 August 2017

issue

10

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3 August 2017

page(s)

1550-1560

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The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

3 August 2017

cites work

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Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1)

7 July 2018

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7 July 2018

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Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.

7 July 2018

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The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation

7 July 2018

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7 July 2018

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Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation

7 July 2018

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7 July 2018

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Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin

7 July 2018

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The proprotein convertases

7 July 2018

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Glucagon-like peptides

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Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1.

7 July 2018

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Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase

7 July 2018

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

7 July 2018

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Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

7 July 2018

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Two activation states of the prohormone convertase PC1 in the secretory pathway

7 July 2018

1 reference

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Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

7 July 2018

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Gastrin biosynthesis in the antrum of patients with pernicious anemia

7 July 2018

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PACE4: a subtilisin-like endoprotease with unique properties

7 July 2018

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High plasma proopiomelanocortin in aggressive adrenocorticotropin-secreting tumors

7 July 2018

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Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

7 July 2018

1 reference

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Role of prohormone convertases in the tissue-specific processing of proglucagon

7 July 2018

1 reference

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Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases.

7 July 2018

1 reference

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Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4

7 July 2018

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Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis.

7 July 2018

1 reference

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The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing.

7 July 2018

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cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

7 July 2018

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Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases

7 July 2018

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Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum

7 July 2018

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Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases

7 July 2018

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7 July 2018

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Proopiomelanocortin-derived peptides

7 July 2018

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Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

7 July 2018

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Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function

7 July 2018

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Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles.

7 July 2018

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Direct measurement of the precursors of adrenocorticotropin in human plasma by two-site immunoradiometric assay.

7 July 2018

1 reference

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The hormonal state of pregnancy: modification of cortisol and testosterone

7 July 2018

1 reference

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Increased tissue concentrations of the gastrin precursor in patients treated with omeprazole.

7 July 2018

1 reference

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Heptadecapeptide gastrin: measurement in blood by specific radioimmunoassay.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=259128

Activation of a prorenin-like substance in human plasma by trypsin and by urinary kallikrein

7 July 2018

1 reference

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Prohormones: their clinical relevance.

7 July 2018

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Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=259128

Proglucagon processing in porcine and human pancreas

26 October 2018

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Phosphorylated forms of adrenocorticotropin and corticotropin-like intermediary lobe peptide in human tumors

9 December 2018

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12 December 2020

9 Processing enzymes of pepsin family: Yeast aspartic protease 3 and pro-opiomelanocortin converting enzyme

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12 December 2020

Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary

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12 December 2020

Measurement of active renin by the 4G1 anti-human renin monoclonal antibody

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12 December 2020

Procalcitonin and its component peptides in systemic inflammation: immunochemical characterization

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12 December 2020

Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation

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12 December 2020

Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2

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12 December 2020

Amino terminal gastrin fragment in serum of Zollinger-Ellison syndrome patients

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12 December 2020

Molecular modeling of the substrate specificity of prohormone convertases SPC2 and SPC3

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12 December 2020

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

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12 December 2020

Purification and characterization of the prohormone convertase PC1(PC3)

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12 December 2020

Serum calcitonin precursors in sepsis and systemic inflammation

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12 December 2020

Identifiers

DOI

10.1172/JCI200318784

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3 August 2017

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3 August 2017

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