Engineered antibody fragments and the rise of single domains (Q34650980)

3 August 2017

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title

Engineered antibody fragments and the rise of single domains (English)

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3 August 2017

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Philipp Holliger

1

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3 August 2017

Peter J Hudson

series ordinal

2

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3 August 2017

publication date

1 September 2005

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3 August 2017

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3 August 2017

volume

23

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3 August 2017

issue

9

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3 August 2017

page(s)

1126-1136

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Escherichia coli secretion of an active chimeric antibody fragment.

3 August 2017

cites work

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7 January 2021

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

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7 January 2021

Single-chain antigen-binding proteins

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7 January 2021

"Diabodies": small bivalent and bispecific antibody fragments

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7 January 2021

The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3

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7 January 2021

Triabodies: single chain Fv fragments without a linker form trivalent trimers

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7 January 2021

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

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7 January 2021

Engineered antibodies

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7 January 2021

Human antibody-Fc receptor interactions illuminated by crystal structures

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7 January 2021

From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling.

1 reference

7 January 2021

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

1 reference

7 January 2021

Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody

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7 January 2021

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.

1 reference

7 January 2021

Strongin VivoMaturation Compensates for Structurally Restricted H3 Loops in Antibody Repertoires

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7 January 2021

Chemical basis for the affinity maturation of a camel single domain antibody

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7 January 2021

Shark immunity bites back: affinity maturation and memory response in the nurse shark,Ginglymostoma cirratum

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7 January 2021

Do sharks have a new antibody lineage?

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7 January 2021

Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor

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7 January 2021

Crystal structure of a shark single-domain antibody V region in complex with lysozyme

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7 January 2021

Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1.

1 reference

7 January 2021

Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH

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7 January 2021

Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen

1 reference

7 January 2021

An S-layer heavy chain camel antibody fusion protein for generation of a nanopatterned sensing layer to detect the prostate-specific antigen by surface plasmon resonance technology

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7 January 2021

Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm

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7 January 2021

Efficient cancer therapy with a nanobody-based conjugate

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7 January 2021

Crystal structure of a human VH: requirements for maintaining a monomeric fragment

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7 January 2021

Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display

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7 January 2021

Crystal structure of HEL4, a soluble, refoldable human V(H) single domain with a germ-line scaffold

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7 January 2021

Aggregation-resistant domain antibodies selected on phage by heat denaturation

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7 January 2021

New binding specificities derived from Min-23, a small cystine-stabilized peptidic scaffold

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7 January 2021

Engineered proteins as specific binding reagents.

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7 January 2021

Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody

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7 January 2021

Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc

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7 January 2021

Antibody multispecificity mediated by conformational diversity

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7 January 2021

New look at an old costimulator

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7 January 2021

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

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7 January 2021

Tumour targeting of humanised cross-linked divalent-Fab' antibody fragments: a clinical phase I/II study

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7 January 2021

Formatting antibody fragments to mediate specific therapeutic functions

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7 January 2021

Single-chain Fv multimers of the anti-neuraminidase antibody NC10: the residue at position 15 in the V(L) domain of the scFv-0 (V(L)-V(H)) molecule is primarily responsible for formation of a tetramer-trimer equilibrium

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7 January 2021

Antigen binding and stability properties of non-covalently linked anti-CD22 single-chain Fv dimers.

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7 January 2021

Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications

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7 January 2021

The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs.

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7 January 2021

Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody

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7 January 2021

Structure of an influenza neuraminidase-diabody complex by electron cryomicroscopy and image analysis

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7 January 2021

The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: implications for diabody flexibility

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7 January 2021

Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody

1 reference

7 January 2021

Integrating cell-level kinetic modeling into the design of engineered protein therapeutics.

1 reference

7 January 2021

Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy

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7 January 2021

A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice

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7 January 2021

Molecular Imaging of Atherosclerotic Plaques Using a Human Antibody Against the Extra-Domain B of Fibronectin

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7 January 2021

Molecular targeting of angiogenesis for imaging and therapy

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7 January 2021

Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting

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7 January 2021

Pharmacodynamic enhancement of the anti-platelet antibody fab abciximab by site-specific pegylation.

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7 January 2021

Retargeting serum immunoglobulin with bispecific diabodies

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7 January 2021

Glycoforms obtained by expression in Pichia pastoris improve cancer targeting potential of a recombinant antibody-enzyme fusion protein

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7 January 2021

Antibodies and gene therapy: teaching old 'magic bullets' new tricks

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7 January 2021

Single-chain antibody and its derivatives directed against vascular endothelial growth factor: application for antiangiogenic gene therapy.

1 reference

7 January 2021

Induction of human T lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted from gene-modified bystander cells.

1 reference

7 January 2021

Intracellular antibodies as specific reagents for functional ablation: future therapeutic molecules

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7 January 2021

De novo production of diverse intracellular antibody libraries

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7 January 2021

Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody

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7 January 2021

Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors.

1 reference

7 January 2021

MTS-conjugated-antiactive caspase 3 antibodies inhibit actinomycin D-induced apoptosis

1 reference

7 January 2021

Nuclear delivery of p53 C-terminal peptides into cancer cells using scFv fragments of a monoclonal antibody that penetrates living cells.

1 reference

7 January 2021

Bispecific human IgG by design

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7 January 2021

A new format of bispecific antibody: highly efficient heterodimerization, expression and tumor cell lysis.

1 reference

7 January 2021

Remodeling domain interfaces to enhance heterodimer formation

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7 January 2021

Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct

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7 January 2021

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct.

1 reference

7 January 2021

Combined effect of recombinant CD19 x CD16 diabody and thalidomide in a preclinical model of human B cell lymphoma

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7 January 2021

T-cell triggering by CD3- and CD28-binding molecules linked to a human virus-modified tumor cell vaccine.

1 reference

7 January 2021

A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity.

1 reference

7 January 2021

Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor

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7 January 2021

Recombinant bispecific antibodies for the targeting of adenoviruses to CEA-expressing tumour cells: a comparative analysis of bacterially expressed single-chain diabody and tandem scFv

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7 January 2021

Drug transport to brain with targeted liposomes

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7 January 2021

A novel bispecific tetravalent antibody fusion protein to target costimulatory activity for T-cell activation to tumor cells overexpressing ErbB2/HER2.

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7 January 2021

Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide, bismuth 213.

1 reference

7 January 2021

Antibody-targeted cell fusion

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7 January 2021

Rescue and propagation of fully retargeted oncolytic measles viruses

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7 January 2021

HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity.

1 reference

7 January 2021

Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice

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7 January 2021

Targeting malignant B-cell lymphoma with a humanized anti-CD22 scFv-angiogenin immunoenzyme.

1 reference

7 January 2021

Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature.

1 reference

7 January 2021

Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice

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7 January 2021

Therapy of human non-small-cell lung carcinoma using antibody targeting of a modified superantigen

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7 January 2021

Engineering high affinity superantigens by phage display

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7 January 2021

Immune cell-mediated antitumor activities of GD2-targeted liposomal c-myb antisense oligonucleotides containing CpG motifs.

1 reference

7 January 2021

Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy

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7 January 2021

Immunization with the gene expressing woodchuck hepatitis virus nucleocapsid protein fused to cytotoxic-T-lymphocyte-associated antigen 4 leads to enhanced specific immune responses in mice and woodchucks.

1 reference

7 January 2021

Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT)

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7 January 2021

In vitro and in vivo characterization of a novel antibody-like single-chain TCR human IgG1 fusion protein

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7 January 2021

Quantum dots for live cells, in vivo imaging, and diagnostics

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7 January 2021

Crystal structure of a soluble CD28-Fab complex

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7 January 2021

Multivalent scFv display of phagemid repertoires for the selection of carbohydrate-specific antibodies and its application to the Thomsen-Friedenreich antigen

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7 January 2021

Selection of optical biosensors from chemisynthetic antibody libraries

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7 January 2021

Microbead display by in vitro compartmentalisation: selection for binding using flow cytometry

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7 January 2021

Isolation of receptor-ligand pairs by capture of long-lived multivalent interaction complexes

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7 January 2021

Induced refolding of a temperature denatured llama heavy-chain antibody fragment by its antigen.

1 reference

7 January 2021

Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo

1 reference

7 January 2021

Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70.

1 reference

7 January 2021

Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies

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7 January 2021

Stabilization of the cold shock protein CspB from Bacillus subtilis by evolutionary optimization of Coulombic interactions

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7 January 2021

Immunoassays based on electrochemical detection using microelectrode arrays

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7 January 2021

Optimized normalization for antibody microarrays and application to serum-protein profiling

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7 January 2021

Chemical remodelling of cell surfaces in living animals

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7 January 2021

High-throughput antibody production

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7 January 2021

UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

7 January 2021

Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging

1 reference

7 January 2021

Preclinical manufacture of anti-HER2 liposome-inserting, scFv-PEG-lipid conjugate. 2. Conjugate micelle identity, purity, stability, and potency analysis

1 reference

7 January 2021

Engineered vascular-targeting antibody-interferon-γ fusion protein for cancer therapy

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7 January 2021

Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer

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7 January 2021

A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B.

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7 January 2021

Identifiers

DOI

10.1038/NBT1142

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release_v7nk7jxw75dnfl7jl6ctptob5m

3 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/v7nk7jxw75dnfl7jl6ctptob5m

24 November 2022

mapped directly with Wikidata item

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