Novel aspects of excitation-contraction coupling in heart failure (Q34652710)

3 August 2017

title

Novel aspects of excitation-contraction coupling in heart failure (English)

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Collaborative Research Centre (CRC) 1002: "Modulatory Units in Heart Failure"

3 August 2017

sponsor

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1 reference

Stefan Neef

1

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3 August 2017

Lars S Maier

series ordinal

2

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3 August 2017

publication date

6 June 2013

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Basic Research in Cardiology

3 August 2017

published in

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3 August 2017

volume

108

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3 August 2017

issue

4

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3 August 2017

page(s)

360

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Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure

3 August 2017

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21 January 2018

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The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium

21 January 2018

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Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation

21 January 2018

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21 January 2018

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21 January 2018

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Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.

21 January 2018

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Spatial and temporal inhomogeneities during Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytes

21 January 2018

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Diastolic heart failure: a misNOmer

21 January 2018

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Heart rate and heart failure. Not a simple relationship

21 January 2018

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Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium

21 January 2018

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Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes.

21 January 2018

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A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice

21 January 2018

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Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

21 January 2018

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Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure

21 January 2018

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Saltatory propagation of Ca2+ waves by Ca2+ sparks

21 January 2018

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A common MLP (muscle LIM protein) variant is associated with cardiomyopathy

21 January 2018

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Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression.

21 January 2018

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Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes

21 January 2018

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Inhibition of Na+/H+-exchanger with sabiporide attenuates the downregulation and uncoupling of the myocardial beta-adrenoceptor system in failing rabbit hearts.

21 January 2018

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Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent

21 January 2018

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Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes

21 January 2018

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Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.

21 January 2018

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Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

21 January 2018

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Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

RAnoLazIne for the treatment of diastolic heart failure in patients with preserved ejection fraction: the RALI-DHF proof-of-concept study

21 January 2018

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Increased SR Ca2+ cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Sorcin interacts with sarcoplasmic reticulum Ca(2+)-ATPase and modulates excitation-contraction coupling in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Ca2+ sparks and Ca2+ waves activate different Ca(2+)-dependent ion channels in single myocytes from rat portal vein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Remodeling of excitation-contraction coupling in the heart: inhibition of sarcoplasmic reticulum Ca(2+) leak as a novel therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Role of RyR2 phosphorylation at S2814 during heart failure progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Impaired left ventricular function in the presence of preserved ejection in chronic hypertensive conscious pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Effects on recovery during acidosis in cardiac myocytes overexpressing CaMKII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Inhibition of Elevated Ca 2+ /Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+) current

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Differential cardiac remodeling in preload versus afterload

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Ca/calmodulin kinase II differentially modulates potassium currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Intracellular calcium release and cardiac disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Protein kinase A phosphorylation at serine-2808 of the cardiac Ca2+-release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Altered intracellular Ca2+ handling in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

Systolic and Diastolic Heart Failure Are Overlapping Phenotypes Within the Heart Failure Spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00395-013-0360-2

10.1007/S00395-013-0360-2

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

3 August 2017

1020792724

0 references

1 reference