JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium (Q36253971)

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English	JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium	scientific article

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29 January 2020

JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium (English)

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29 January 2020

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M Sacherer

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P Wakuła

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M A Vos

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J Kockskämper

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P Stiegler

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M Sereinigg

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D von Lewinski

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G Antoons

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B M Pieske

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F R Heinzel

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CONTICA investigators

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1 October 2012

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29 January 2020

British Journal of Pharmacology

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493-504

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3

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29 January 2020

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30 September 2017

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30 September 2017

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

1 reference

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30 September 2017

Pharmacological characteristics and clinical applications of K201.

1 reference

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30 September 2017

Ryanodine receptor-mediated arrhythmias and sudden cardiac death.

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30 September 2017

What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?

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30 September 2017

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts

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30 September 2017

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes.

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30 September 2017

Calcium cycling and signaling in cardiac myocytes.

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30 September 2017

Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release.

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30 September 2017

Molecular and electrophysiological bases of catecholaminergic polymorphic ventricular tachycardia

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30 September 2017

K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449255

30 September 2017

CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation.

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30 September 2017

Abnormal intrastore calcium signaling in chronic heart failure

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30 September 2017

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure

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30 September 2017

Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor.

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30 September 2017

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

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30 September 2017

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

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30 September 2017

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

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29 June 2018

Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity.

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29 June 2018

Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.

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22 September 2018

CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449255

22 September 2018

Ultrastructural and functional remodeling of the coupling between Ca2+ influx and sarcoplasmic reticulum Ca2+ release in right atrial myocytes from experimental persistent atrial fibrillation

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22 September 2018

Function of Ca(2+) release channels in Purkinje cells that survive in the infarcted canine heart: a mechanism for triggered Purkinje ectopy.

1 reference

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22 September 2018

Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation

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22 September 2018

Frequency-dependence of the slow force response

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22 September 2018

Pharmacological inhibition of na/ca exchange results in increased cellular Ca2+ load attributable to the predominance of forward mode block.

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22 September 2018

Remodeling of T-tubules and reduced synchrony of Ca2+ release in myocytes from chronically ischemic myocardium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449255

22 September 2018

Calcium spark properties in ventricular myocytes are altered in aged mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449255

22 September 2018

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449255

22 September 2018

Insulin causes [Ca2+]i-dependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449255

22 September 2018

Defective cardiac ryanodine receptor regulation during atrial fibrillation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449255

22 September 2018

Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.

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22 September 2018

Decreased Ca2+ extrusion via Na+/Ca2+ exchange in epicardial left ventricular myocytes during compensated hypertrophy

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22 September 2018

Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure

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22 September 2018

Spatial and temporal inhomogeneities during Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytes

1 reference

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22 September 2018

A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449255

22 September 2018

Quantitative assessment of the SR Ca2+ leak-load relationship

1 reference

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22 September 2018

Calcium sparks in human ventricular cardiomyocytes from patients with terminal heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449255

22 September 2018

The sarcoplasmic reticulum and the Na+/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does Ca2+/calmodulin-dependent protein kinase deltac activate or inhibit the cardiac ryanodine receptor ion channel?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cardioprotective effects of a new 1,4-benzothiazepine derivative, JTV519, on ischemia/reperfusion-induced Ca2+ overload in isolated rat hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22509897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2012.01995.X

1 reference

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29 January 2020

1 reference

Europe PubMed Central

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29 January 2020

1 reference

Europe PubMed Central

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29 January 2020

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