Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir (Q34657222)

3 August 2017

title

Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir (English)

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3 August 2017

1 reference

3

Irene T Weber

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3 August 2017

Andrey Y Kovalevsky

1

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3 August 2017

Arun K Ghosh

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

20 September 2008

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Journal of Medicinal Chemistry

3 August 2017

published in

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3 August 2017

volume

51

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3 August 2017

issue

20

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3 August 2017

page(s)

6599-6603

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Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance

3 August 2017

cites work

1 reference

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Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114

7 July 2018

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Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

7 July 2018

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TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates

7 July 2018

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Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease

7 July 2018

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New approaches toward anti-HIV chemotherapy

7 July 2018

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Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor

7 July 2018

1 reference

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Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

7 July 2018

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Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition.

7 July 2018

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Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes

7 July 2018

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Inhibitors of HIV-1 protease: a major success of structure-assisted drug design

7 July 2018

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Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease

7 July 2018

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Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors

7 July 2018

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Haloperidol-based irreversible inhibitors of the HIV-1 and HIV-2 proteases

7 July 2018

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Why is uncompetitive inhibition so rare? A possible explanation, with implications for the design of drugs and pesticides

7 July 2018

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Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.

7 July 2018

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Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution

7 July 2018

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Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier

7 July 2018

1 reference

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Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.

26 October 2018

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High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains

26 October 2018

1 reference

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Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites

26 October 2018

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26 October 2018

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Investigation of an allosteric site of HIV-1 proteinase involved in inhibition by Cu2+

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18808097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18808097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18808097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM800283K

1 reference

3 August 2017

1 reference

3 August 2017

1 reference