Teratogenic effects of thalidomide: molecular mechanisms (Q34660391)

3 August 2017

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title

Teratogenic effects of thalidomide: molecular mechanisms (English)

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3 August 2017

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Takumi Ito

1

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3 August 2017

Hideki Ando

series ordinal

2

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3 August 2017

Hiroshi Handa

series ordinal

3

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3 August 2017

publication date

5 January 2011

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Cellular and Molecular Life Sciences

3 August 2017

published in

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3 August 2017

volume

68

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3 August 2017

issue

9

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3 August 2017

page(s)

1569-1579

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https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

3 August 2017

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The evolution of thalidomide and its IMiD derivatives as anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide-induced limb defects: resolving a 50-year-old puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

21 January 2018

Thalidomide embryopathy

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

A short history of thalidomide embryopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide a promising new treatment for rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide for the therapy of graft-versus-host disease following allogeneic bone marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide inhibits the replication of human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide is an inhibitor of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Antitumor activity of thalidomide in refractory multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

S.T.E.P.S.: a comprehensive program for controlling and monitoring access to thalidomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide, a current teratogen in South America

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Identification of a primary target of thalidomide teratogenicity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Intravenous formulations of the enantiomers of thalidomide: pharmacokinetic and initial pharmacodynamic characterization in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide pharmacokinetics and metabolite formation in mice, rabbits, and multiple myeloma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

An autopodial-like pattern of Hox expression in the fins of a basal actinopterygian fish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Fin development in a cartilaginous fish and the origin of vertebrate limbs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Fgf8 is required for outgrowth and patterning of the limbs

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Fgf8 signalling from the AER is essential for normal limb development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Proposed mechanisms of action in thalidomide embryopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Hypothesis: thalidomide embryopathy-proposed mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Mechanism of action in thalidomide teratogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Biochemical toxicology of chemical teratogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

PTEN function: how normal cells control it and tumour cells lose it

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Stages of embryonic development of the zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Development and application of high-performance affinity beads: toward chemical biology and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

High-performance affinity beads for identifying drug receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Development of novel magnetic nano-carriers for high-performance affinity purification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Cereblon is expressed in the retina and binds to voltage-gated chloride channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Function and regulation of cullin-RING ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Back to the future with ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Animal models of human disease: zebrafish swim into view

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Effective targeted gene 'knockdown' in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Induction of cereblon by NF-E2-related factor 2 in neuroblastoma cells exposed to hypoxia-reoxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Molecular mechanism of nrf2 activation by oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

A gene atlas of the mouse and human protein-encoding transcriptomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Formation of the digestive system in zebrafish. II. Pancreas morphogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide resistance is based on the capacity of the glutathione-dependent antioxidant defense.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Use of the rat postimplantation embryo culture to assess the embryotoxic potency within a chemical category and to identify toxic metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

A new mechanism of methotrexate action revealed by target screening with affinity beads.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Efficacy of lenalidomide in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Lenalidomide for the treatment of B-cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

Thalidomide analogues as anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

New cases of thalidomide embryopathy in Brazil

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0619-9

DRUG TESTING IN ANIMALS FOR TERATOGENIC EFFECTS. THALIDOMIDE IN THE PREGNANT RAT

21 January 2018

1 reference

12 December 2020

Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species-dependent

1 reference

12 December 2020

Treatment of Behçet's disease with thalidomide

1 reference

12 December 2020

Thalidomide for the treatment of chronic graft-versus-host disease

1 reference

12 December 2020

THALIDOMIDE IN THE TREATMENT OF LEPRA REACTIONS

1 reference

12 December 2020

Imperforate anus in 700,000 consecutive liveborn infants

1 reference

12 December 2020

Thalidomide metabolism by the CYP2C subfamily.

1 reference

12 December 2020

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

1 reference

12 December 2020

The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor

1 reference

12 December 2020

The saga of thalidomide. Neuropathy to embryopathy, with case reports of congenital anomalies

1 reference

12 December 2020

BMPs negatively regulate structure and function of the limb apical ectodermal ridge.

1 reference

12 December 2020

Thalidomide metabolites in mice and patients with multiple myeloma

1 reference

12 December 2020

Teratogen metabolism: thalidomide activation is mediated by cytochrome P-450

1 reference

12 December 2020

Plasma pharmacokinetics and urinary excretion of thalidomide after oral dosing in healthy male volunteers

1 reference

12 December 2020

TERATOGENIC EFFECTS OF THALIDOMIDE IN RABBITS, RATS, HAMSTERS, AND MICE

1 reference

12 December 2020

The development of the paired fins in the Zebrafish (Danio rerio)

1 reference

12 December 2020

Antiangiogenic activity of N-substituted and tetrafluorinated thalidomide analogues

1 reference

12 December 2020

Treatment of the cutaneous lesions of systemic lupus erythematosus with thalidomide

1 reference

12 December 2020

10.1007/S00018-010-0619-9

Identifiers

DOI

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3 August 2017

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