The unfolded protein response in nutrient sensing and differentiation (Q34664763)

3 August 2017

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title

The unfolded protein response in nutrient sensing and differentiation (English)

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positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

3 August 2017

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0006990

endoplasmic reticulum unfolded protein response

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Gene Ontology release 2020-05-02

Randal J Kaufman

1

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3 August 2017

Donalyn Scheuner

2

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3 August 2017

Martin Schröder

3

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3 August 2017

Xiaohua Shen

4

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3 August 2017

Kyungho Lee

5

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3 August 2017

Chuan Yin Liu

6

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3 August 2017

Stacey M Arnold

7

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3 August 2017

1 June 2002

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Nature Reviews Molecular Cell Biology

3 August 2017

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3 August 2017

3

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3 August 2017

6

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3 August 2017

411-421

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https://scigraph.springernature.com/pub.10.1038/nrm829

3 August 2017

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cites work

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

31 March 2020

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Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

31 March 2020

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Reversible phosphorylation of eukaryotic initiation factor 2 alpha in response to endoplasmic reticular signaling

31 March 2020

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Tripartite management of unfolded proteins in the endoplasmic reticulum

31 March 2020

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Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation

31 March 2020

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Mammalian stress response: induction of the glucose-regulated protein family

31 March 2020

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Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels

31 March 2020

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How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum

31 March 2020

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Recognition of local glycoprotein misfolding by the ER folding sensor UDP-glucose:glycoprotein glucosyltransferase

31 March 2020

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Genetic tailoring of N-linked oligosaccharides: the role of glucose residues in glycoprotein processing of Saccharomyces cerevisiae in vivo

31 March 2020

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Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus

31 March 2020

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The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation

31 March 2020

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

31 March 2020

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A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

31 March 2020

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Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response

31 March 2020

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tRNA ligase is required for regulated mRNA splicing in the unfolded protein response

31 March 2020

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mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response

31 March 2020

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Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response

31 March 2020

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Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source

31 March 2020

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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

31 March 2020

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Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway

31 March 2020

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A regulatory link between ER-associated protein degradation and the unfolded-protein response

31 March 2020

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IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae

31 March 2020

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The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane

31 March 2020

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A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

31 March 2020

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Cloning of mammalian Ire1 reveals diversity in the ER stress responses

31 March 2020

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A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

31 March 2020

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The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

31 March 2020

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

31 March 2020

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Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

31 March 2020

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

31 March 2020

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Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

31 March 2020

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

31 March 2020

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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

31 March 2020

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

31 March 2020

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ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

31 March 2020

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ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

31 March 2020

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Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response

31 March 2020

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

31 March 2020

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The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

31 March 2020

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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

31 March 2020

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Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins

31 March 2020

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The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core

31 March 2020

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Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

31 March 2020

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

31 March 2020

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Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.

31 March 2020

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

31 March 2020

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The control of filamentous differentiation and virulence in fungi.

31 March 2020

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Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae

31 March 2020

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The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast

31 March 2020

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Plasma cell differentiation requires the transcription factor XBP-1

31 March 2020

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Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately

31 March 2020

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

31 March 2020

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Perk is essential for translational regulation and cell survival during the unfolded protein response

31 March 2020

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The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins

31 March 2020

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Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?

31 March 2020

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

31 March 2020

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EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

31 March 2020

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Translational control of proinsulin synthesis by glucose

31 March 2020

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Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

31 March 2020

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Effects of chronically elevated glucose levels on the functional properties of rat pancreatic beta-cells

31 March 2020

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Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM829

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Dimensions Publication ID

3 August 2017

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