Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma (Q34666165)

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English	Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma	scientific article

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Europe PubMed Central

PubMed publication ID

3 August 2017

Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Anja Müller

1

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Europe PubMed Central

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3 August 2017

Chuanbing Zang

2

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Europe PubMed Central

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3 August 2017

Cindrilla Chumduri

3

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Europe PubMed Central

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3 August 2017

Bernd Dörken

4

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Europe PubMed Central

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3 August 2017

Peter T Daniel

5

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3 August 2017

Christian W Scholz

6

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3 August 2017

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publication date

15 June 2013

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3 August 2017

International Journal of Cancer

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3 August 2017

133

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PubMed publication ID

3 August 2017

8

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Europe PubMed Central

PubMed publication ID

3 August 2017

1813-1824

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Europe PubMed Central

PubMed publication ID

3 August 2017

Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Mcl-1 is a potential therapeutic target in multiple types of cancer

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

mTORC1 promotes survival through translational control of Mcl-1.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: The University of Chicago phase II consortium

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Dual requirement for a newly identified phosphorylation site in p70s6k

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https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

New Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

ABT-737 induces apoptosis in mantle cell lymphoma cells with a Bcl-2high/Mcl-1low profile and synergizes with other antineoplastic agents

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Responses in Mantle Cell Lymphoma Cells to SNS-032 Depend on the Biological Context of Each Cell Line

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma

1 reference

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21 January 2018

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

1 reference

https://api.crossref.org/works/10.1002%2FIJC.28206

21 January 2018

Identifiers

10.1002/IJC.28206

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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