Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors (Q34667012)

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Language	Label	Description	Also known as
English	Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors (English)

1 reference

Europe PubMed Central

3 August 2017

0 references

author name string

George G Holz

1

1 reference

Europe PubMed Central

3 August 2017

Oleg G Chepurny

2

1 reference

Europe PubMed Central

3 August 2017

Frank Schwede

3

1 reference

Europe PubMed Central

3 August 2017

publication date

25 July 2007

1 reference

Europe PubMed Central

3 August 2017

number of pages

11

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based on heuristic

inferred from page(s)

Cellular Signalling

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Europe PubMed Central

3 August 2017

20

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Europe PubMed Central

3 August 2017

10-20

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Europe PubMed Central

3 August 2017

1

1 reference

Europe PubMed Central

3 August 2017

cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling

1 reference

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Structural insight into substrate specificity of phosphodiesterase 10

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Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways

1 reference

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Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

1 reference

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Epac and the cardiovascular system

1 reference

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Cyclic AMP-dependent protein kinase and Epac mediate cyclic AMP responses in pancreatic acini

1 reference

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Capturing cyclic nucleotides in action: snapshots from crystallographic studies

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Dissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling

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Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.

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Epac proteins: multi-purpose cAMP targets

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Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.

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A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation

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Cell physiology of cAMP sensor Epac

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Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes

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Molecular details of cAMP generation in mammalian cells: a tale of two systems

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Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells

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ABCC8 and ABCC9: ABC transporters that regulate K+ channels

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7 July 2018

Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton

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7 July 2018

Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation

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Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells

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An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

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cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells

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7 July 2018

Differential modulation of Cav1.2 and Cav1.3-mediated glucose-stimulated insulin secretion by cAMP in INS-1 cells: distinct roles for exchange protein directly activated by cAMP 2 (Epac2) and protein kinase A.

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7 July 2018

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation

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7 July 2018

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

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7 July 2018

Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC).

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7 July 2018

Multiple cAMP-induced signaling cascades regulate prolactin expression in T cells

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7 July 2018

The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane

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Dopamine regulation of amiloride-sensitive sodium channels in lung cells.

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Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets

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7 July 2018

Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting

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7 July 2018

PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis

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7 July 2018

Techniques: promiscuous Galpha proteins in basic research and drug discovery

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7 July 2018

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

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7 July 2018

Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line

1 reference

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7 July 2018

Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

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Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system

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7 July 2018

International Union of Pharmacology. XLVI. G protein-coupled receptor list.

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7 July 2018

Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway

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Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis

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Toward linking structure with function in ATP-sensitive K+ channels

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7 July 2018

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

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7 July 2018

Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments

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7 July 2018

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors

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7 July 2018

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

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7 July 2018

Novel single chain cAMP sensors for receptor-induced signal propagation.

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7 July 2018

Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A

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7 July 2018

Localized effects of cAMP mediated by distinct routes of protein kinase A.

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7 July 2018

Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

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7 July 2018

cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells

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7 July 2018

Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis

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7 July 2018

cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension

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7 July 2018

Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac

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7 July 2018

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells

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7 July 2018

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

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7 July 2018

Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor

1 reference

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7 July 2018

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

1 reference

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7 July 2018

Structure and regulation of the cAMP-binding domains of Epac2

1 reference

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7 July 2018

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

1 reference

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7 July 2018

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

1 reference

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7 July 2018

Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis

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7 July 2018

A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases

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7 July 2018

Cyclic nucleotide-gated ion channels

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7 July 2018

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

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7 July 2018

Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B

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7 July 2018

A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

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7 July 2018

cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells

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7 July 2018

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

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7 July 2018

Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.

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7 July 2018

Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells

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7 July 2018

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

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7 July 2018

Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells

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7 July 2018

A family of cAMP-binding proteins that directly activate Rap1

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7 July 2018

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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7 July 2018

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains

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7 July 2018

G proteins: transducers of receptor-generated signals

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7 July 2018

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases in

1 reference

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7 July 2018

The phenotypic differentiation of locus ceruleus noradrenergic neurons mediated by brain-derived neurotrophic factor is enhanced by corticotropin releasing factor through the activation of a cAMP-dependent signaling pathway.

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26 October 2018

Calcium-induced acrosomal exocytosis requires cAMP acting through a protein kinase A-independent, Epac-mediated pathway

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26 October 2018

cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

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26 October 2018

Cyclic AMP/cAMP-GEF pathway amplifies insulin exocytosis induced by Ca2+ and ATP in rat islet beta-cells

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26 October 2018

cAMP increases Ca2+-dependent exocytosis through both PKA and Epac2 in mouse melanotrophs from pituitary tissue slices

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26 October 2018

A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells

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26 October 2018

Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity

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26 October 2018

Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.

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26 October 2018

Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic beta-cells

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26 October 2018

Epac: a new cAMP target and new avenues in cAMP research

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26 October 2018

Direct modulation of synaptic vesicle priming by GABA(B) receptor activation at a glutamatergic synapse

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26 October 2018

Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2215344

26 October 2018

(RP)-cAMPS inhibits the cAMP-dependent protein kinase by blocking the cAMP-induced conformational transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epac1 regulates integrity of endothelial cell junctions through VE-cadherin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for existence of cAMP-Epac signaling in the heads of mouse epididymal spermatozoa

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon activates Ca2+ and Cl- channels in rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epac-mediated Ca(2+) mobilization and exocytosis in inner medullary collecting duct

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EP2 receptor stimulation promotes calcium responses in astrocytes via activation of the adenylyl cyclase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel mechanisms of the regulation of protein kinase B in adipocytes; implications for protein kinase A, Epac, phosphodiesterases 3 and 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17716863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CELLSIG.2007.07.009

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

ResearchGate publication ID

0 references

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