XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation (Q34669732)

3 August 2017

title

XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation (English)

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3 August 2017

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A Errami

1

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3 August 2017

D M He

2

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3 August 2017

A A Friedl

3

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3 August 2017

W J Overkamp

4

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3 August 2017

B Morolli

5

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3 August 2017

E A Hendrickson

6

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3 August 2017

F Eckardt-Schupp

7

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3 August 2017

M Oshimura

8

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3 August 2017

P H Lohman

9

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3 August 2017

S P Jackson

10

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3 August 2017

M Z Zdzienicka

11

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3 August 2017

language of work or name

English

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publication date

1 July 1998

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3 August 2017

published in

Nucleic Acids Research

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3 August 2017

volume

26

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3 August 2017

issue

13

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3 August 2017

page(s)

3146-3153

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describes a project that uses

3 August 2017

XR-C1

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cites work

Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint

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Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20

7 July 2018

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Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks

7 July 2018

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Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development

7 July 2018

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Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

7 July 2018

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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

7 July 2018

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7 July 2018

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Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors

7 July 2018

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The end-joining reaction in V(D)J recombination

7 July 2018

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Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

7 July 2018

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DNA looping by Ku and the DNA-dependent protein kinase

7 July 2018

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Ku proteins join DNA fragments as shown by atomic force microscopy

7 July 2018

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A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation

7 July 2018

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Characterization of two DNA double-stranded break repair-deficient cell lines that express inactive DNA-dependent protein kinase catalytic subunits

7 July 2018

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An ionizing radiation-sensitive CHO mutant cell line: irs-20. IV. Genetic complementation, V(D)J recombination and the scid phenotype

7 July 2018

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Regulation and repair of double-strand DNA breaks

7 July 2018

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Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

7 July 2018

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Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes

7 July 2018

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Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

7 July 2018

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

7 July 2018

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Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

7 July 2018

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Restoration of X-ray and etoposide resistance, Ku-end binding activity and V(D) J recombination to the Chinese hamster sxi-3 mutant by a hamster Ku86 cDNA.

7 July 2018

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An electrophoretic approach to the assessment of the spatial distribution of DNA double-strand breaks in mammalian cells

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

7 July 2018

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Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8.

7 July 2018

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Human chromosome 8 (p12-->q22) complements radiosensitivity in the severe combined immune deficiency (SCID) mouse.

7 July 2018

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Expression and V(D)J recombination activity of mutated RAG-1 proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

A human gene that restores the DNA-repair defect in SCID mice is located on 8p11.1-->q11.1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Complementation of the radiosensitive phenotype in severe combined immunodeficient mice by human chromosome 8.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Mitotic regulation of a TATA-binding-protein-containing complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Complementation analysis of the murine scid cell line.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

A novel type of X-ray-sensitive Chinese hamster cell mutant with radioresistant DNA synthesis and hampered DNA double-strand break repair

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

DNA double-strand break repair in two radiation-sensitive mouse mammary carcinoma cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

An ionizing radiation-sensitive mutant of CHO cells: irs-20. I. Isolation and initial characterization.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Cell cycle responses of two X-ray sensitive mutants defective in DNA repair

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Construction of mouse A9 clones containing a single human chromosome tagged with neomycin-resistance gene via microcell fusion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Characterization of an X-ray-hypersensitive mutant of V79 Chinese hamster cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

A DNA-activated protein kinase from HeLa cell nuclei

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

In situ hybridization with fluoresceinated DNA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

The SCID mouse mutant: definition, characterization, and potential uses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

A link between double-strand break-related repair and V(D)J recombination: the scid mutation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

The nuclear serine/threonine protein kinase DNA-PK

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

The murine DNA-PKcs gene consists of 86 exons dispersed in more than 250 kb.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

Mutagen-sensitive cell lines are obtained with a high frequency in V79 Chinese hamster cells.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=147672

The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement

26 October 2018

1 reference

12 December 2020

V(D)J recombination: a functional definition of the joining signals

1 reference

12 December 2020

The scid mutation in mice causes a general defect in DNA repair

1 reference

12 December 2020

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/26.13.3146

1 reference

journals/nar/ErramiHFOMHEOLJZ98

3 August 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

3 August 2017

1 reference