Gene conversion: mechanisms, evolution and human disease (Q34685613)

3 August 2017

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title

Gene conversion: mechanisms, evolution and human disease (English)

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Gene Ontology release 2020-05-02

3 August 2017

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2

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3 August 2017

Nadia Chuzhanova

3

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George P Patrinos

series ordinal

5

object named as

George P Patrinos

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3 August 2017

1

Jian-Min Chen

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3 August 2017

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Claude Férec

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3 August 2017

11 September 2007

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3 August 2017

Nature Reviews Genetics

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3 August 2017

8

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3 August 2017

762-775

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3 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrg2193

3 August 2017

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cites work

Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology

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The mismatch repair system reduces meiotic homeologous recombination and stimulates recombination-dependent chromosome loss

21 January 2018

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Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.

21 January 2018

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Recombination proteins in yeast

31 March 2020

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The double-strand-break repair model for recombination

31 March 2020

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Repairing a double-strand chromosome break by homologous recombination: revisiting Robin Holliday's model

31 March 2020

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The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination

31 March 2020

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Conservative inheritance of newly synthesized DNA in double-strand break-induced gene conversion

31 March 2020

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Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast

31 March 2020

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Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover

31 March 2020

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Molecular dissection of mitotic recombination in the yeast Saccharomyces cerevisiae

31 March 2020

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DNA helicase Srs2 disrupts the Rad51 presynaptic filament

31 March 2020

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The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

31 March 2020

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Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein

31 March 2020

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Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing

31 March 2020

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Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.

31 March 2020

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DNA strand displacement, strand annealing and strand swapping by the Drosophila Bloom's syndrome helicase

31 March 2020

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Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.

31 March 2020

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Rad54 protein promotes branch migration of Holliday junctions

31 March 2020

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The Bloom's syndrome helicase suppresses crossing over during homologous recombination

31 March 2020

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Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1.

31 March 2020

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Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration

31 March 2020

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Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants

31 March 2020

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BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates

31 March 2020

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A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.

31 March 2020

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Differential timing and control of noncrossover and crossover recombination during meiosis

31 March 2020

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Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis

31 March 2020

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Happy Hollidays: 40th anniversary of the Holliday junction

31 March 2020

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Gene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeats

31 March 2020

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Proceedings of the SMBE Tri-National Young Investigators' Workshop 2005. Genome-wide search of gene conversions in duplicated genes of mouse and rat

31 March 2020

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Human meiotic recombination products revealed by sequencing a hotspot for homologous strand exchange in multiple HNPP deletion patients

31 March 2020

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Contribution of gene conversion in the evolution of the human beta-like globin gene family

31 March 2020

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Dynamics of a human interparalog gene conversion hotspot

31 March 2020

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New HLA-DPB1 alleles generated by interallelic gene conversion detected by analysis of sperm

31 March 2020

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Intense and highly localized gene conversion activity in human meiotic crossover hot spots

31 March 2020

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Breakpoints of gross deletions coincide with non-B DNA conformations

31 March 2020

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Transcription of a donor enhances its use during double-strand break-induced gene conversion in human cells

31 March 2020

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A two-locus gene conversion model with selection and its application to the human RHCE and RHD genes

31 March 2020

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Segmental duplications and gene conversion: Human luteinizing hormone/chorionic gonadotropin beta gene cluster.

31 March 2020

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Signatures of selection and gene conversion associated with human color vision variation

31 March 2020

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Primate evolution of an olfactory receptor cluster: diversification by gene conversion and recent emergence of pseudogenes.

31 March 2020

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Evolution of the interferon alpha gene family in eutherian mammals

31 March 2020

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Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state

31 March 2020

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Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: a potential mechanism for receptor dimerization.

31 March 2020

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Finely orchestrated movements: evolution of the ribosomal RNA genes

31 March 2020

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Abundant gene conversion between arms of palindromes in human and ape Y chromosomes.

31 March 2020

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Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFa deletion hotspots

31 March 2020

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Haplotype diversity in the human red and green opsin genes: evidence for frequent sequence exchange in exon 3.

31 March 2020

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Estimates of L:M cone ratio from ERG flicker photometry and genetics

31 March 2020

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The orthology of HLA-E and H2-Qa1 is hidden by their concerted evolution with other MHC class I molecules.

31 March 2020

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Sequence variation at the human ABO locus.

31 March 2020

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Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles.

31 March 2020

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Are 100,000 "SNPs" useless?

31 March 2020

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Recent segmental duplications in the human genome

31 March 2020

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31 March 2020

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Traffic of genetic information between segmental duplications flanking the typical 22q11.2 deletion in velo-cardio-facial syndrome/DiGeorge syndrome

31 March 2020

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A genome-wide comparison of recent chimpanzee and human segmental duplications

31 March 2020

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Finishing the euchromatic sequence of the human genome

31 March 2020

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Evidence for widespread reticulate evolution within human duplicons

31 March 2020

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Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion

31 March 2020

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Insights into recombination from patterns of linkage disequilibrium in humans

31 March 2020

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A haplotype map of the human genome

31 March 2020

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A worldwide survey of haplotype variation and linkage disequilibrium in the human genome

31 March 2020

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Transferability of tag SNPs in genetic association studies in multiple populations

31 March 2020

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Close look at gene conversion hot spots

31 March 2020

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Genome-wide tagging for everyone

31 March 2020

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A chromosomal rearrangement hotspot can be identified from population genetic variation and is coincident with a hotspot for allelic recombination

31 March 2020

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Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion.

31 March 2020

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A fine-scale map of recombination rates and hotspots across the human genome

31 March 2020

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Live hot, die young: transmission distortion in recombination hotspots

31 March 2020

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New insights into the biological basis of genomic disorders.

31 March 2020

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Divergent outcomes of intrachromosomal recombination on the human Y chromosome: male infertility and recurrent polymorphism

31 March 2020

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Genomic context of paralogous recombination hotspots mediating recurrent NF1 region microdeletion.

31 March 2020

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Insights into recombination from population genetic variation

31 March 2020

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Estimating the rate of gene conversion on human chromosome 21.

31 March 2020

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Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels

31 March 2020

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Factors influencing recombination frequency and distribution in a human meiotic crossover hotspot.

31 March 2020

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Allelic recombination and de novo deletions in sperm in the human beta-globin gene region

31 March 2020

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Biased gene conversion: implications for genome and sex evolution

31 March 2020

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Gene conversion drives GC content evolution in mammalian histones

31 March 2020

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The influence of recombination on human genetic diversity

31 March 2020

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Human polymorphism around recombination hotspots: Figure 1

31 March 2020

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Context-dependent mutation rates may cause spurious signatures of a fixation bias favoring higher GC-content in humans.

31 March 2020

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Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl

31 March 2020

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A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

31 March 2020

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Gene conversions are a common cause of von Willebrand disease

31 March 2020

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Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication

31 March 2020

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Elevated rates of sister chromatid exchange at chromosome ends

31 March 2020

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Mucopolysaccharidosis type I: identification of novel mutations that cause Hurler/Scheie syndrome in Chinese families

31 March 2020

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A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics.

31 March 2020

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A homozygous nonsense mutation in SOX9 in the dominant disorder campomelic dysplasia: a case of mitotic gene conversion.

31 March 2020

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An apparent interlocus gene conversion-like event at a putative tumor suppressor gene locus on human chromosome 6q27 in a Burkitt's lymphoma cell line

31 March 2020

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Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers.

31 March 2020

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Novel biallelic mutations in MSH6 and PMS2 genes: gene conversion as a likely cause of PMS2 gene inactivation.

31 March 2020

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Regulation of 3' splice site selection in the 844ins68 polymorphism of the cystathionine Beta -synthase gene.

31 March 2020

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Diversity of cystathionine beta-synthase haplotypes bearing the most common homocystinuria mutation c.833T>C: a possible role for gene conversion

31 March 2020

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Revertant mosaicism in epidermolysis bullosa caused by mitotic gene conversion

31 March 2020

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Inverse correlation between SMN1 and SMN2 copy numbers: evidence for gene conversion from SMN2 to SMN1.

31 March 2020

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The potential of oligonucleotides for therapeutic applications

31 March 2020

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Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

31 March 2020

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Identification and purification of two distinct complexes containing the five RAD51 paralogs

31 March 2020

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RAD51C is required for Holliday junction processing in mammalian cells

31 March 2020

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DNA repair: keeping it together

31 March 2020

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Human Rad50/Mre11 is a flexible complex that can tether DNA ends

31 March 2020

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Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

31 March 2020

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Association of BRCA1 with Rad51 in mitotic and meiotic cells

31 March 2020

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

31 March 2020

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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

31 March 2020

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Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.

31 March 2020

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Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats

31 March 2020

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Potential Gene Conversion and Source Genes for Recently Integrated Alu Elements

31 March 2020

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Sequence correlation between neighboring Alu instances suggests post-retrotransposition sequence exchange due to Alu gene conversion

31 March 2020

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Human genomic deletions mediated by recombination between Alu elements.

31 March 2020

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A double-strand break in a chromosomal LINE element can be repaired by gene conversion with various endogenous LINE elements in mouse cells

31 March 2020

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Characterization of in vivo recombination activities in the mouse embryo

31 March 2020

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A comprehensive analysis of recently integrated human Ta L1 elements

31 March 2020

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Following the LINEs: an analysis of primate genomic variation at human-specific LINE-1 insertion sites

31 March 2020

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Mechanism of Alu integration into the human genome

31 March 2020

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Molecular evolution and tempo of amplification of human LINE-1 retrotransposons since the origin of primates.

31 March 2020

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Immunoglobulin gene diversification

31 March 2020

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Sequence transfers between variable regions in a mouse antibody transgene can occur by gene conversion

31 March 2020

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Gene conversion in human rearranged immunoglobulin genes

31 March 2020

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De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome

31 March 2020

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Diversity of the CYP21A2 gene: a 6.2-kb TaqI fragment and a 3.2-kb TaqI fragment mistaken as CYP21A1P.

31 March 2020

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CYP21A2 mutations in Portuguese patients with congenital adrenal hyperplasia: Identification of two novel mutations and characterization of four different partial gene conversions

31 March 2020

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Aberrant splicing and missense mutations cause steroid 21-hydroxylase [P-450(C21)] deficiency in humans: possible gene conversion products

31 March 2020

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Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production

31 March 2020

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A unique form of autosomal dominant cataract explained by gene conversion between beta-crystallin B2 and its pseudogene

31 March 2020

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Folate pathway gene alterations in patients with neural tube defects

31 March 2020

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Mutation analysis in 46 British and Irish patients with Gaucher's disease

31 March 2020

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Prevalent and rare mutations among Gaucher patients

31 March 2020

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Sequence of two alleles responsible for Gaucher disease

31 March 2020

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Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature

31 March 2020

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Hemoglobin Parchman: double crossover within a single human gene

31 March 2020

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The Cretan type of non-deletional hereditary persistence of fetal hemoglobin [A gamma-158C-->T] results from two independent gene conversion events.

31 March 2020

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Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia

31 March 2020

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Mutational analysis of patients with p47-phox-deficient chronic granulomatous disease: The significance of recombination events between the p47-phox gene (NCF1) and its highly homologous pseudogenes

31 March 2020

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Gene conversion between red and defective green opsin gene in blue cone monochromacy

31 March 2020

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Gene conversion is a likely cause of mutation in PKD1.

31 March 2020

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Mutation analysis in PKD1 of Japanese autosomal dominant polycystic kidney disease patients

31 March 2020

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Identification of novel mutations in patients with Shwachman-Diamond syndrome

31 March 2020

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Novel SBDS mutations caused by gene conversion in Japanese patients with Shwachman-Diamond syndrome

31 March 2020

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Mutations in SBDS are associated with Shwachman-Diamond syndrome

31 March 2020

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A frame-shift deletion in the survival motor neuron gene in Spanish spinal muscular atrophy patients

31 March 2020

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Multiple substitutions in the von Willebrand factor gene that mimic the pseudogene sequence.

31 March 2020

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Mutations of von Willebrand factor gene in families with von Willebrand disease in the Aland Islands

31 March 2020

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von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure

31 March 2020

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Homozygous gene conversion in von Willebrand factor gene as a cause of type 3 von Willebrand disease and predisposition to inhibitor development

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG2193

1 reference

PubMed ID

17846636

Dimensions Publication ID

3 August 2017

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PubMed ID

17846636