Parkinson's disease: one biochemical pathway to fit all genes? (Q34688339)

3 August 2017

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title

Parkinson's disease: one biochemical pathway to fit all genes? (English)

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3 August 2017

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4

Jörg B Schulz

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3 August 2017

3

Olaf Riess

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3 August 2017

1

Rejko Krüger

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3 August 2017

Olaf Eberhardt

2

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3 August 2017

1 May 2002

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Trends in Molecular Medicine

3 August 2017

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3 August 2017

8

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3 August 2017

5

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3 August 2017

236-240

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Understanding cell death in Parkinson's disease.

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

From entropy to Duino

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https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Dopaminergic function in familial Parkinson's disease: A clinical and18F-dopa positron emission tomography study

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Parkinson's disease in twins studied with 18F-dopa and positron emission tomography

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Familial Aggregation of Parkinson's Disease in Iceland

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Association between early-onset Parkinson's disease and mutations in the parkin gene

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

The ubiquitin pathway in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

A susceptibility locus for Parkinson's disease maps to chromosome 2p13.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

1 reference

7 January 2021

Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Genome-wide scan for Parkinson's disease: the GenePD Study

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Complete genomic screen in Parkinson disease: evidence for multiple genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

alpha-synuclein gene haplotypes are associated with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Failure of the ubiquitin-proteasome system in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Degradation of alpha-synuclein by proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Proteasomal function is impaired in substantia nigra in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Alpha synuclein in neurodegenerative disorders: murderer or accomplice?

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Lewy bodies and parkinsonism in families with parkin mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

The ubiquitin system for protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

No genetic association of the Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Lack of association between ubiquitin carboxy-terminal hydrolase L1 gene polymorphism and PD

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

The septin CDCrel-1 is dispensable for normal development and neurotransmitter release

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Synphilin-1 is present in Lewy bodies in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

Untangling tau-related dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

PARK6-linked parkinsonism occurs in several European families.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902333-X

7 January 2021

10.1016/S1471-4914(02)02333-X

Identifiers

DOI

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3 August 2017

1 reference

PubMed ID

12067634