Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria (Q34693880)

4 August 2017

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria (English)

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4 August 2017

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Jacques Chollet

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4 August 2017

Darren J Creek

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Susan A. Charman

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Susan A Charman

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William N. Charman

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William N Charman

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Sergio Wittlin

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object named as

Sergio Wittlin

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4 August 2017

Sarah Arbe-Barnes

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4 August 2017

Ian C Bathurst

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4 August 2017

Reto Brun

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4 August 2017

Michael Campbell

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4 August 2017

Francis C K Chiu

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4 August 2017

J Carl Craft

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4 August 2017

Yuxiang Dong

11

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4 August 2017

Hugues Matile

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4 August 2017

Melanie Maurer

13

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4 August 2017

Julia Morizzi

14

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4 August 2017

Tien Nguyen

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4 August 2017

Petros Papastogiannidis

16

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4 August 2017

Christian Scheurer

17

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4 August 2017

David M Shackleford

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4 August 2017

Kamaraj Sriraghavan

19

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4 August 2017

Lukas Stingelin

20

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4 August 2017

Yuanqing Tang

21

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4 August 2017

Heinrich Urwyler

22

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4 August 2017

Xiaofang Wang

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4 August 2017

Karen L White

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4 August 2017

Lin Zhou

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4 August 2017

Jonathan L Vennerstrom

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4 August 2017

language of work or name

English

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publication date

7 February 2011

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Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

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4 August 2017

108

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4 August 2017

11

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4 August 2017

4400-4405

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Arterolane, a new synthetic trioxolane for treatment of uncomplicated Plasmodium falciparum malaria: a phase II, multicenter, randomized, dose-finding clinical trial

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

The molecular mechanism of action of artemisinin--the debate continues.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Artemisinin resistance: current status and scenarios for containment

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

New medicines to improve control and contribute to the eradication of malaria

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

The global portfolio of new antimalarial medicines under development.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Qinghaosu (Artemisinin): The Price of Success

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Ensuring sustained ACT production and reliable artemisinin supply

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

The antimalarial drug artemisinin alkylates heme in infected mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Identification of an antimalarial synthetic trioxolane drug development candidate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Synthetic peroxides as antimalarials

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

A medicinal chemistry perspective on artemisinin and related endoperoxides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Antimalarial drug resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Artemisinins target the SERCA of Plasmodium falciparum

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Artemisinin: mechanisms of action, resistance and toxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Medical need, scientific opportunity and the drive for antimalarial drugs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Assessment of the pharmacodynamic properties of antimalarial drugs in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

The infectivity of gametocytes of Plasmodium falciparum from patients treated with artemisinin.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

Malaria's drug miracle in danger.

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015762108

Malaria. Did they really say ... eradication?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015762108

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015762108

Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015762108

Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015762108

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015762108

Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015762108

Quantum chemical study of the intermediate complex required for iron-mediated reactivity and antimalarial activity of dispiro-1,2,4-trioxolanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015762108

The role of Product Development Partnerships in research and development for neglected diseases.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060245

In vivo use of the P450 inactivator 1-aminobenzotriazole in the rat: varied dosing route to elucidate gut and liver contributions to first-pass and systemic clearance

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21300861

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1015762108

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference