Medical need, scientific opportunity and the drive for antimalarial drugs (Q34521004)

2 August 2017

1 reference

title

Medical need, scientific opportunity and the drive for antimalarial drugs (English)

1 reference

2 August 2017

0 references

Robert G Ridley

1

1 reference

PubMed ID

11832957

2 August 2017

language of work or name

English

0 references

publication date

1 February 2002

1 reference

2 August 2017

1 reference

2 August 2017

415

1 reference

2 August 2017

6872

1 reference

2 August 2017

686-693

1 reference

https://scigraph.springernature.com/pub.10.1038/415686a

2 August 2017

0 references

cites work

Thalidomide: current and potential clinical applications

1 reference

7 January 2021

Chloroquine-resistant malaria

1 reference

7 January 2021

Dihydrofolate reductase and antifolate resistance in malaria

1 reference

7 January 2021

4-Aminoquinolines--past, present, and future: a chemical perspective

1 reference

7 January 2021

Artemisinin drugs: novel antimalarial agents

1 reference

7 January 2021

Artemisinin and derivatives: the future for malaria treatment?

1 reference

7 January 2021

Assessment of the pharmacodynamic properties of antimalarial drugs in vivo

1 reference

7 January 2021

Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine

1 reference

7 January 2021

Arteether-induced brain injury in Macaca mulatta. I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei.

1 reference

7 January 2021

Severe allergic reactions to oral artesunate: a report of two cases

1 reference

7 January 2021

Desbutyl-benflumetol, a novel antimalarial compound: in vitro activity in fresh isolates of Plasmodium falciparum from Thailand

1 reference

7 January 2021

In vitro activity of lumefantrine (benflumetol) against clinical isolates of Plasmodium falciparum in Yaoundé, Cameroon.

1 reference

7 January 2021

Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria

1 reference

7 January 2021

Cost-effectiveness of sulfadoxine-pyrimethamine for the prevention of malaria-associated low birth weight.

1 reference

7 January 2021

Therapeutic efficacy of sulphadoxine/pyrimethamine and susceptibility in vitro of P. falciparum isolates to sulphadoxine-pyremethamine and other antimalarial drugs in Malawian children

1 reference

7 January 2021

Drug resistance in malaria

1 reference

7 January 2021

Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group

1 reference

7 January 2021

A plastid organelle as a drug target in apicomplexan parasites.

1 reference

7 January 2021

Antimalarial drug development and new targets

1 reference

7 January 2021

Emerging targets for antimalarial drugs

1 reference

7 January 2021

A brief illustrated guide to the ultrastructure of Plasmodium falciparum asexual blood stages

1 reference

7 January 2021

Hemoglobin metabolism in the malaria parasite Plasmodium falciparum

1 reference

7 January 2021

Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.

1 reference

7 January 2021

Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum

1 reference

7 January 2021

Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum

1 reference

7 January 2021

The structure of malaria pigment beta-haematin

1 reference

7 January 2021

Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites

1 reference

7 January 2021

On the molecular mechanism of chloroquine's antimalarial action

1 reference

7 January 2021

Access to hematin: the basis of chloroquine resistance.

1 reference

7 January 2021

A common mechanism for blockade of heme polymerization by antimalarial quinolines

1 reference

7 January 2021

The chemical basis for the ferriprotoporphyrin IX-chloroquine complex induced lipid peroxidation

1 reference

7 January 2021

Chloroquine - some open questions on its antimalarial mode of action and resistance

1 reference

7 January 2021

Possible modes of action of the artemisinin-type compounds.

1 reference

7 January 2021

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

1 reference

7 January 2021

Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.

1 reference

7 January 2021

Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum

1 reference

7 January 2021

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

1 reference

7 January 2021

Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine

1 reference

7 January 2021

Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores

1 reference

7 January 2021

Reversal of chloroquine resistance in Plasmodium falciparum by verapamil

1 reference

7 January 2021

A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum

1 reference

7 January 2021

Enhanced efficacy of chloroquine-chlorpheniramine combination in acute uncomplicated falciparum malaria in children

1 reference

7 January 2021

A plastid of probable green algal origin in Apicomplexan parasites.

1 reference

7 January 2021

Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum

1 reference

7 January 2021

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

1 reference

7 January 2021

Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

1 reference

7 January 2021

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

1 reference

7 January 2021

Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity

1 reference

7 January 2021

Mitochondria of mammalian Plasmodium spp.

1 reference

7 January 2021

Phenyl beta-methoxyacrylates: a new antimalarial pharmacophore.

1 reference

7 January 2021

Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs

1 reference

7 January 2021

Chemotherapy for falciparum malaria: the armoury, the problems and the prospects

1 reference

7 January 2021

The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug

1 reference

7 January 2021

An overview of chemotherapeutic targets for antimalarial drug discovery

1 reference

7 January 2021

The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design

1 reference

7 January 2021

Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter

1 reference

7 January 2021

Membrane transport in the malaria-infected erythrocyte

1 reference

7 January 2021

A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite.

1 reference

7 January 2021

Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets

1 reference

7 January 2021

An overview of Plasmodium protein kinases.

1 reference

7 January 2021

The role of genomics in antibacterial target discovery

1 reference

7 January 2021

Advances in structural genomics

1 reference

7 January 2021

Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine

1 reference

7 January 2021

Transfection of malaria parasites.

1 reference

7 January 2021

Plasmodium: drug discovery and development--an industrial perspective

1 reference

7 January 2021

Role of the development scientist in compound lead selection and optimization

1 reference

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

7 January 2021

A new global commitment to disease control in Africa

1 reference

7 January 2021

Identifiers

DOI

10.1038/415686A

1 reference

PubMed ID

11832957

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

11832957