Neutrophil elastase inhibitors as treatment for COPD. (Q34706998)

4 August 2017

1 reference

title

Neutrophil elastase inhibitors as treatment for COPD. (English)

1 reference

4 August 2017

Hiroyuki Ohbayashi

1

1 reference

PubMed ID

12084007

4 August 2017

language of work or name

English

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publication date

1 July 2002

1 reference

Expert Opinion on Investigational Drugs

4 August 2017

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4 August 2017

11

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4 August 2017

965-980

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4 August 2017

7

1 reference

Regional patterns of disability-free life expectancy and disability-adjusted life expectancy: global Burden of Disease Study.

4 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

21 January 2018

Novel therapy for COPD.

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Future Advances in COPD Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Current Status of Small Airways Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Chronic obstructive pulmonary disease: risk factors, pathophysiology and pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Tumour necrosis factor-alpha-induced ICAM-1 expression in human vascular endothelial and lung epithelial cells: modulation by tyrosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Role of complement, chemokines, and regulatory cytokines in acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Primary structure of human neutrophil elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Neutrophil proteinases. Caution signs in designing inhibitors against enzymes with possible multiple functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Mucus Hypersecretion in Bronchiectasis: The Role of Neutrophil Proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Reduction of ciliary beat frequency in vitro by sputum from patients with bronchiectasis: a serine proteinase effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Secretory leukoprotease inhibitor: partnering alpha 1-proteinase inhibitor to combat pulmonary inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Cytokine-mediated induction of the human elafin gene in pulmonary epithelial cells is regulated by nuclear factor-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Elafin is induced in epidermis in skin disorders with dermal neutrophilic infiltration: interleukin-1 beta and tumour necrosis factor-alpha stimulate its secretion in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Human neutrophil elastase regulates the expression and secretion of elafin (elastase-specific inhibitor) in type II alveolar epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Protection against acute lung injury by intravenous or intratracheal pretreatment with EPI-HNE-4, a new potent neutrophil elastase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

ONO-5046, a novel inhibitor of human neutrophil elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Gabexate mesilate, a synthetic protease inhibitor, attenuates endotoxin-induced pulmonary vascular injury by inhibiting tumor necrosis factor production by monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Neutrophil elastase inhibitor, ONO-5046, modulates acid-induced lung and systemic injury in rabbits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Neutrophil elastase inhibitor, ONO-5046 suppresses ozone-induced airway mucus hypersecretion in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

The kinetic mechanism of inhibition of human leukocyte elastase by MR889, a new cyclic thiolic compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

IBC's conference on pulmonary hypertension: new understanding for therapeutic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Development of orally active nonpeptidic inhibitors of human neutrophil elastase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Influence of positive end-expiratory pressure on right and left ventricular performance assessed by Doppler two-dimensional echocardiography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Inhibition of Serine Proteinases Belonging to the Chymotrypsin Superfamily by the Cyclic Thiolic Compound YS3025: A Comparative Crystallographic Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.11.7.965

10.1517/13543784.11.7.965

21 January 2018

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12084007