Challenges for blood-brain barrier (BBB) screening (Q34707666)

4 August 2017

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title

Challenges for blood-brain barrier (BBB) screening (English)

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4 August 2017

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Jeffrey P

1

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4 August 2017

Summerfield SG

series ordinal

2

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4 August 2017

language of work or name

English

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publication date

1 October 2007

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4 August 2017

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4 August 2017

volume

37

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4 August 2017

issue

10-11

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4 August 2017

page(s)

1135-1151

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Astrocyte-endothelial interactions at the blood-brain barrier

4 August 2017

cites work

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One hundred years of membrane permeability: does Overton still rule?

21 January 2018

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The distribution of the HIV protease inhibitor, ritonavir, to the brain, cerebrospinal fluid, and choroid plexuses of the guinea pig.

21 January 2018

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Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid

21 January 2018

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Evaluation of the utility of brain slice methods to study brain penetration

21 January 2018

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An enzymic barrier mechanism for monoamine precursors in the newly-forming brain capillaries following electrolytic or mechanical lesions

21 January 2018

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Clinical pharmacokinetics of cerebrospinal fluid

21 January 2018

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In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics.

21 January 2018

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P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists

21 January 2018

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Characterization of (+/-)-methadone uptake by rat lung

21 January 2018

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New perspectives on the theory of permeability and resistance in the study of drug transport and absorption.

21 January 2018

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In silico prediction of blood–brain barrier permeation

21 January 2018

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Drug targeting to the brain.

21 January 2018

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The role of drug transporters at the blood-brain barrier

21 January 2018

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Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling

21 January 2018

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The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

21 January 2018

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Assessment of blood-brain barrier penetration: in silico, in vitro and in vivo

21 January 2018

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The pharmacology of headache

21 January 2018

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Positron emission tomography compartmental models

21 January 2018

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Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu).

21 January 2018

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Structure-brain exposure relationships

21 January 2018

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The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.

21 January 2018

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Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

21 January 2018

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Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

21 January 2018

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Kinetic analyses for species differences in P-glycoprotein-mediated drug transport.

21 January 2018

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Correlation of blood-brain penetration using structural descriptors

21 January 2018

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Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding

21 January 2018

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Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

21 January 2018

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Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

21 January 2018

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Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding

21 January 2018

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Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.

21 January 2018

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Bovine brain endothelial cells express tight junctions and monoamine oxidase activity in long-term culture.

21 January 2018

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Expression and function of cytochrome p450 in brain drug metabolism

21 January 2018

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Impact of drug transporter studies on drug discovery and development

21 January 2018

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In vivo evidence for the efflux transport of pentazocine from the brain across the blood-brain barrier using the brain efflux index method

21 January 2018

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In silico ADME modelling: prediction models for blood-brain barrier permeation using a systematic variable selection method

21 January 2018

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Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells

21 January 2018

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Computational approaches to the prediction of the blood-brain distribution

21 January 2018

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Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid/plasma concentration ratio

21 January 2018

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Blood-brain barrier delivery

21 January 2018

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Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin

21 January 2018

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The role of blood-brain barrier studies in the pharmaceutical industry

21 January 2018

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Local controlled drug delivery to the brain: mathematical modeling of the underlying mass transport mechanisms

21 January 2018

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The fluid mosaic model of the structure of cell membranes

21 January 2018

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Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells

21 January 2018

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In vitro prediction of brain penetration - a case for free thinking?

21 January 2018

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Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

21 January 2018

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Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

21 January 2018

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Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport

21 January 2018

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Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.

21 January 2018

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Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier.

21 January 2018

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Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition

21 January 2018

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Caco-2 cell permeability assays to measure drug absorption.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701570285

Lipophilicity in PK design: methyl, ethyl, futile

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701570285

Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701570285

10.1080/00498250701570285

21 January 2018

Identifiers

DOI

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4 August 2017

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