Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin (Q34715776)

4 August 2017

title

Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin (English)

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4 August 2017

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Jonathan W Wojtkowiak

1

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4 August 2017

Komal M Sane

2

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4 August 2017

Miriam Kleinman

3

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4 August 2017

Bonnie F Sloane

4

1 reference

4 August 2017

John J Reiners

5

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4 August 2017

Raymond R Mattingly

6

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4 August 2017

language of work or name

English

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publication date

12 January 2011

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Journal of Pharmacology and Experimental Therapeutics

4 August 2017

published in

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4 August 2017

volume

337

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4 August 2017

issue

1

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4 August 2017

page(s)

65-74

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Working together: Farnesyl transferase inhibitors and statins block protein prenylation

4 August 2017

cites work

1 reference

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A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells

7 July 2018

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The late endosome is essential for mTORC1 signaling

7 July 2018

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Autophagy: regulation and role in disease

7 July 2018

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Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis

7 July 2018

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Suppression of proliferation of two independent NF1 malignant peripheral nerve sheath tumor cell lines by the pan-ErbB inhibitor CI-1033.

7 July 2018

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Autophagy induced by farnesyltransferase inhibitors in cancer cells

7 July 2018

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Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline

7 July 2018

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Does autophagy have a license to kill mammalian cells?

7 July 2018

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Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells

7 July 2018

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Induction of apoptosis in neurofibromatosis type 1 malignant peripheral nerve sheath tumor cell lines by a combination of novel farnesyl transferase inhibitors and lovastatin

7 July 2018

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A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments

7 July 2018

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Autophagy: from phenomenology to molecular understanding in less than a decade

7 July 2018

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How to interpret LC3 immunoblotting

7 July 2018

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Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as farnesyltransferase inhibitors

7 July 2018

1 reference

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The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80.

7 July 2018

1 reference

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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

7 July 2018

1 reference

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Does autophagy contribute to cell death?

7 July 2018

1 reference

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Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1.

7 July 2018

1 reference

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The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines

7 July 2018

1 reference

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Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis

7 July 2018

1 reference

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The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity

7 July 2018

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The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death

7 July 2018

1 reference

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Rheb binds and regulates the mTOR kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Intensive versus moderate lipid lowering with statins after acute coronary syndromes

7 July 2018

1 reference

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Potent suppression of proliferation of a10 vascular smooth muscle cells by combined treatment with lovastatin and 3-allylfarnesol, an inhibitor of protein farnesyltransferase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Role of LAMP-2 in lysosome biogenesis and autophagy

7 July 2018

1 reference

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The autophagosomal-lysosomal compartment in programmed cell death

7 July 2018

1 reference

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Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway

7 July 2018

1 reference

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Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes

7 July 2018

1 reference

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Regulation of the mevalonate pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft.

7 July 2018

1 reference

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Hydrophobic statins induce autophagy in cultured human rhabdomyosarcoma cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Down-regulation of growth factor-stimulated MAP kinase signaling in cytotoxic drug-resistant human neuroblastoma cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063739

Farnesyltransferase inhibitors

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21228063

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/JPET.110.174573

1 reference

4 August 2017

1 reference

4 August 2017

1 reference