IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection (Q34717852)

4 August 2017

IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection (English)

1 reference

4 August 2017

0 references

Jason S Stumhofer

1

1 reference

4 August 2017

Jonathan S Silver

series ordinal

2

1 reference

4 August 2017

Christopher A Hunter

series ordinal

3

1 reference

4 August 2017

language of work or name

English

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publication date

7 May 2013

1 reference

4 August 2017

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4 August 2017

8

1 reference

4 August 2017

5

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4 August 2017

e62889

1 reference

Creative Commons Attribution 4.0 International

4 August 2017

start time

7 May 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation

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IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation

7 July 2018

1 reference

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Follicular helper CD4 T cells (TFH)

7 July 2018

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Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers

7 July 2018

1 reference

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The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.

7 July 2018

1 reference

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In vivo regulation of Bcl6 and T follicular helper cell development

7 July 2018

1 reference

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Regulation of CD8+ T cell responses to infection with parasitic protozoa

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

7 July 2018

1 reference

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IL-21 and T follicular helper cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

7 July 2018

1 reference

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Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii

7 July 2018

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A vital role for interleukin-21 in the control of a chronic viral infection

7 July 2018

1 reference

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IL-21 is required to control chronic viral infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

IL-21 mediates suppressive effects via its induction of IL-10.

7 July 2018

1 reference

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The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

A fundamental role for interleukin-21 in the generation of T follicular helper cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer

7 July 2018

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Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

7 July 2018

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

IL-27 limits IL-2 production during Th1 differentiation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

A critical role for IL-21 in regulating immunoglobulin production

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

Deficient humoral responses underlie susceptibility to Toxoplasma gondii in CD4-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase.

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062889

A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062889

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062889

Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062889

IL-21 promotes survival and maintains a naive phenotype in human CD4+ T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062889

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647013

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23667536

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23667536

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Western Blot analysis of the antigens of Toxoplasma gondii recognized by human IgM and IgG antibodies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23667536

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0062889

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference