Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. (Q34730569)

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English	Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates.	scientific article

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31 December 2019

Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates (English)

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31 December 2019

Robert E Hampson

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31 December 2019

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Sam A Deadwyler

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31 December 2019

Linda Porrino

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31 December 2019

Jerome M Siegel

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31 December 2019

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1 December 2007

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31 December 2019

Journal of Neuroscience

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31 December 2019

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31 December 2019

52

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31 December 2019

14239-14247

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31 December 2019

Orexin A but not orexin B rapidly enters brain from blood by simple diffusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothalamic hypocretin (orexin): robust innervation of the spinal cord

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https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

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Distribution of orexin neurons in the adult rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local cerebral glucose utilization in the normal conscious macaque monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

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https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

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Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptides crossing the blood-brain barrier: some unusual observations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin (orexin) deficiency in human narcolepsy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced number of hypocretin neurons in human narcolepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SB-334867-A: the first selective orexin-1 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Template images for nonhuman primate neuroimaging: 2. Macaque

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of total sleep deprivation on cerebral responses to cognitive performance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

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Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SB-334867-A antagonises orexin mediated excitation in the locus coeruleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: Validation of method

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

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Binding interactions between peptides and proteins of the class II major histocompatibility complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

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Release of hypocretin (orexin) during waking and sleep states.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Categorization in the monkey hippocampus: a possible mechanism for encoding information into memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurotransmitters of sleep.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell biology of antigen processing in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral correlates of activity in identified hypocretin/orexin neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin/orexin selectively increases dopamine efflux within the prefrontal cortex: involvement of the ventral tegmental area

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The orexin-1 receptor antagonist SB-334867 blocks the effects of antipsychotics on the activity of A9 and A10 dopamine neurons: implications for antipsychotic therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promotion of sleep by targeting the orexin system in rats, dogs and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin (orexin) loss in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin (orexin) cell loss in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MRI-PET registration with automated algorithm

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurons containing hypocretin (orexin) project to multiple neuronal systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/18160631

12 December 2020

based on heuristic

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Identifiers

10.1523/JNEUROSCI.3878-07.2007

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18160631%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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Europe PubMed Central

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31 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18160631%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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