Oxidative stress and diabetic neuropathy: pathophysiological mechanisms and treatment perspectives (Q34733625)

4 August 2017

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title

Oxidative stress and diabetic neuropathy: pathophysiological mechanisms and treatment perspectives (English)

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4 August 2017

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P Sytze van Dam

1

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4 August 2017

1 May 2002

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Diabetes - Metabolism: Research and Reviews

4 August 2017

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4 August 2017

18

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4 August 2017

3

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4 August 2017

176-184

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Diabetic neuropathy: pathogenesis and therapy

4 August 2017

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Diabetic neuropathy--a continuing enigma

21 January 2018

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Experimental diabetic neuropathy: an update

21 January 2018

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Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy

21 January 2018

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Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications

21 January 2018

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Glycation (non-enzymic glycosylation) inactivates glutathione reductase

21 January 2018

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Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications

21 January 2018

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Relationship between glutathione and sorbitol concentrations in erythrocytes from diabetic patients

21 January 2018

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Measurement of Na(+)-K+ pump current in isolated rabbit ventricular myocytes using the whole-cell voltage-clamp technique. Inhibition of the pump by oxidant stress.

21 January 2018

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Different sensitivities of the Na+/K(+)-ATPase isoforms to oxidants.

21 January 2018

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Neurons undergo apoptosis in animal and cell culture models of diabetes.

21 January 2018

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Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve

21 January 2018

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Oxygen toxicity in the nervous tissue: comparison of the antioxidant defense of rat brain and sciatic nerve

21 January 2018

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Antioxidants in peripheral nerve

21 January 2018

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Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.

21 January 2018

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Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy

21 January 2018

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Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state

21 January 2018

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Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals

21 January 2018

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Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats.

21 January 2018

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Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents

21 January 2018

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Depletion of taurine in experimental diabetic neuropathy: implications for nerve metabolic, vascular, and functional deficits

21 January 2018

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Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy

21 January 2018

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The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy

21 January 2018

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A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy.

21 January 2018

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The effect of gamma-linolenic acid-alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats.

21 January 2018

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

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Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy

21 January 2018

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Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Deutsche Kardiale Autonome Neuropathie

21 January 2018

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Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials

21 January 2018

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Reversal of defective nerve conduction with vitamin E supplementation in type 2 diabetes: a preliminary study

21 January 2018

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Metabolic and vascular factors in the pathogenesis of diabetic neuropathy

21 January 2018

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Significance of fructose-induced protein oxidation and formation of advanced glycation end product

21 January 2018

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Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

21 January 2018

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Effect of aldose reductase inhibition on glutathione redox status in erythrocytes of diabetic patients

21 January 2018

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The increase in lipid peroxidation in diabetic rat lens can be reversed by oral sorbinil

21 January 2018

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Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-alpha-lipoic acid

21 January 2018

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Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats

21 January 2018

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Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats

21 January 2018

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Evaluation of a sorbitol dehydrogenase inhibitor on diabetic peripheral nerve metabolism: a prevention study

21 January 2018

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Restoration of Na(+)-K+ pump activity and resting membrane potential by myo-inositol supplementation in neuroblastoma cells chronically exposed to glucose or galactose

21 January 2018

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Lipid peroxidation as the mechanism of modification of the affinity of the Na+, K+-ATPase active sites for ATP, K+, Na+, and strophanthidin in vitro

21 January 2018

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Alpha-lipoic acid: antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy

21 January 2018

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Effect of alpha-tocopherol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve

21 January 2018

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Protein kinase C effects on nerve function, perfusion, Na(+), K(+)-ATPase activity and glutathione content in diabetic rats

21 January 2018

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Decreased glutathione peroxidase activity in sciatic nerve of alloxan-induced diabetic mice and its correlation with blood glucose levels

21 January 2018

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Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat

21 January 2018

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Effects of insulin treatment on endoneurial and systemic oxidative stress in relation to nerve conduction in streptozotocin-diabetic rats

21 January 2018

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Nerve function and oxidative stress in diabetic and vitamin E-deficient rats

21 January 2018

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Nerve conduction and antioxidant levels in experimentally diabetic rats: effects of streptozotocin dose and diabetes duration

21 January 2018

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Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats

21 January 2018

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Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat

21 January 2018

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Effects of the sulphydryl donor N-acetyl-L-cysteine on nerve conduction, perfusion, maturation and regeneration following freeze damage in diabetic rats

21 January 2018

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Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats

21 January 2018

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Nerve function and regeneration in diabetic and galactosaemic rats: antioxidant and metal chelator effects

21 January 2018

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Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine

21 January 2018

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Reversal of peripheral nerve conduction and perfusion deficits by the free radical scavenger, BM15.0639, in diabetic rats

21 January 2018

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Effects of alpha-tocopherol on nerve conduction velocity and regeneration following a freeze lesion in immature diabetic rats

21 January 2018

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High rat food vitamin E content improves nerve function in streptozotocin-diabetic rats

21 January 2018

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Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids

21 January 2018

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alpha-Lipoic acid corrects neuropeptide deficits in diabetic rats via induction of trophic support

21 January 2018

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Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy

21 January 2018

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Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study)

21 January 2018

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Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy

21 January 2018

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Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy

21 January 2018

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Pathology and pathogenetic mechanisms of diabetic neuropathy.

21 January 2018

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7 January 2021

The role of oxidative stress in neuropathy and other diabetic complications

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7 January 2021

Nerve Na+-K+-ATPase, conduction, and myo-inositol in the insulin-deficient BB rat

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7 January 2021

Interaction between oxidative stress and gamma-linolenic acid in impaired neurovascular function of diabetic rats

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7 January 2021

Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes

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7 January 2021

Identifiers

DOI

10.1002/DMRR.287

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4 August 2017

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PubMed ID

12112935